Relationship between severity of HIV infection and ocular pathology in patients with pulmonary tuberculosis
DOI:
https://doi.org/10.31288/oftalmolzh201855659Keywords:
HIV, ocular tuberculosis, CD4 cellsAbstract
Background: Pulmonary tuberculosis most commonly develops and often becomes generalized among HIV-infected patients. HIV-positive individuals present extra-pulmonary forms of tuberculosis twice as often as HIV-negative individuals.
Purpose: To determine the frequency of ocular pathology and the relationship between ocular pathology and CD4 cell count in HIV-positive patients with tuberculosis.
Materials and Methods: Three thousand and eighty four patients with pulmonary tuberculosis including 320 (10.4%) patients co-infected with HIV underwent examination at the City Tuberculosis Dispensary between 2014 and 2016.
Results: Allergic or toxic retinal vasculitides and peripheral focal chorioretinitis of tuberculous etiology in either active or inactive inflammatory phase were most common ocular disorders among HIV-positive patients with marked immune deficiency. In these patients, median CD4 cell count was ≤200-300 cells/mm3 compared to the norm of 1600 cells/mm3.
References
Bloom B. Tuberculosis: Pathogenesis, Protection and Control. Washington DC: American Society for Microbiology Press; 1995.https://doi.org/10.1128/9781555818357
Mellors JW, Munoz A, Giorgi JV, et al. Plasma viral load and CD4 lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med. 1997 Jun 15;126(12):946-54.https://doi.org/10.7326/0003-4819-126-12-199706150-00003
Aerts D, Jobim R. The epidemiological profile of tuberculosis in southern Brazil in times of AIDS. Int J Tuberc Lung Dis. 2004 Jun;8(6):785-91
Karachunskii MA. [Tuberculosis in HIV infection]. Probl Tuberk. 2000;(1):47-52. Russian
Frolova OP. [Tuberculosis in patients with HIV infection: clinic-morphological and epidemiological aspects]. Probl Tuberk. 2002;(6):30-3. Russian
Panteleev AM, Savina TA, Suprun TIu. [Extrapulmonary tuberculosis in HIV-infected patients]. In: [Socially important infections]. St Petersburg;2007. pp. 35-6. Russian
Khokkanen VM. [Ocular tuberculosis]. In: [Brozhenko CS, editor. Extra-pulmonary tuberculosis]. St Petersburg: SPETSLIT;2013. pp. 375-92 Russian
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 И. Н. Воронова, В. М. Хокканен, С. Н. Санаева, М. В. Жемкова
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.
