Clinical and OCT features of different types and stages of diabetic optic neuropathy
DOI:
https://doi.org/10.31288/oftalmolzh201814348Keywords:
diabetic optic neuropathy, clinical and OCT features, ganglion cell complex focal loss volume, peripapillary RNFL thicknessAbstract
Background: The advent of optical coherence tomography (OCT) has offered new opportunities for differential diagnosis of diabetic optic neuropathy (DON).
Purpose: To identify clinical and OCT features of different types and stages of DON.
Materials and Methods: A total of 575 patients (1150 eyes) with type 2 diabetes mellitus (T2DM) were included in the prospective analysis of the features of optic nerve damage. For comparison, we used data from a group of 50 age- and sex-matched healthy control patients. In addition to routine ocular examination, patients underwent ophthalmochromoscopy, OCT of the retina and optic nerve, and electrical physiological studies.
Results: In diabetic papillopathy, anterior ischemic DON, and degenerative-, advanced-, mild-, and subclinical-stage axial DON groups, mean ganglion cell complex focal loss volume values were 21.7, 20.5, 17.3, 13.4, 10.3, and 7.5 times higher, respectively, than in controls. In diabetic papillopathy, anterior ischemic DON, and advanced-stage axial DON groups, mean peripapillary retinal thickness values were 92.2%, 84.7%, and 38.7% higher, respectively, than in controls, whereas in subclinical-, mild-, and degenerative-stage axial DON groups, the values were 8.0%, 13.8%, and 20.5% lower, respectively, than in controls.
Conclusion: We have identified clinical and OCT features of different types and stages of DON in patients with T2DM.
References
Gogina IF, Andriyuk LV, Ogranovych OE. [Diabetic angio-, retino-, neuropathy: pathogenesis, clinical picture, and treatment]. Lviv: Liga press; 2000. Ukrainian
Zhaboiedov GD. [Innovations in diagnosis and treatment of diabetic optic neuropathy]. Mezhdunar Med Zh. 2002;8(1-2):92-7. Russian
Krasavina MI, Astakhov SY, Shadrichev FE, Dal' NY. [Ophthalmic markers of diabetic polyneuropathy]. Oftal'mologicheskie vedomosti. 2016;IX (1):38-46. Russian https://doi.org/10.17816/OV9138-46
Nedzvetskaia OV, Chumak SA. [Clinical and functional characteristics of changes in the optic nerve in juvenile diabetic retinopathy]. Vestn Oftalmol. 2001 May-Jun;117(3):7-11. Russian
Skrypnyk RL. [Optic nerve lesions at the diabetes mellitus (pathogenesis, clinical picture, diagnostics, treatment)]. [Dr. Sc. (Med) Dissertation Abstract]. Odesa: Filatov Institute of Eye Disease; 2005. 34 p. Ukrainian
Tsyrenzhapova RB. [Peripheral nervous system injury in carbohydrate metabolism impairments]. [Cand Sc (Med) Thesis Abstract]. Tomsk: Siberian State Medical University; 2015. 129 p. Russian
Carpineto P, Toto L, Aloia R, et al. Neuroretinal alterations in the early stages of diabetic retinopathy in patients with type 2 diabetes mellitus. Eye (Lond). 2016 May;30(5):673-9 https://doi.org/10.1038/eye.2016.13
Vit VV. [Structure of the human visual system] Odessa: Astroprint; 2003. Russian
Chen X, Nie C, Gong Y, et al. Peripapillary Retinal Nerve Fiber Layer Changes in Preclinical Diabetic Retinopathy: A Meta-Analysis. PLoS One. 2015; 10(5): e0125919. https://doi.org/10.1371/journal.pone.0125919
Leung CKS, Lam S, Weinreb RN, et al. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: analysis of the retinal nerve fiber layer map for glaucoma detection. Ophthalmology. 2010 Sep;117(9):1684-91. https://doi.org/10.1016/j.ophtha.2010.01.026
Strouthidis NG, Fortune B, Yang H, et al. Longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma. Invest Ophthalmol Vis Sci. 2011 Mar 2;52(3):1206-19. https://doi.org/10.1167/iovs.10-5599
Townsend KA, Wollstein G, Schuman JS. Imaging of the retinal nerve fibre layer for glaucoma. Br J Ophthalmol. 2009 Feb;93(2):139-43.https://doi.org/10.1136/bjo.2008.145540
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 П. А. Бездітко, М. А. Карлійчук
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.
