The Short-term efficacy of a monoclonal antibody fragment (brolucizumab) for treating neovascular age-related macular degeneration

Authors

  • A. F. Yusupov Republican Specialized Scientific and Practical Medical Center for Eye Microsurgery, Tashkent, Uzbekistan
  • M. Kh. Karimova Republican Specialized Scientific and Practical Medical Center for Eye Microsurgery, Tashkent, Uzbekistan
  • S. A. Djamalova Republican Specialized Scientific and Practical Medical Center for Eye Microsurgery, Tashkent, Uzbekistan
  • D. K. Makhkamova Republican Specialized Scientific and Practical Medical Center for Eye Microsurgery, Tashkent, Uzbekistan
  • S. I. Abdullaeva Republican Specialized Scientific and Practical Medical Center for Eye Microsurgery, Tashkent, Uzbekistan
  • M. A. Zakirkhodjaeva Republican Specialized Scientific and Practical Medical Center for Eye Microsurgery, Tashkent, Uzbekistan
  • Khodjaeva Zilola Republican Specialized Scientific and Practical Medical Center for Eye Microsurgery, Tashkent, Uzbekistan
  • D. A. Rakhimova Republican Specialized Scientific and Practical Medical Center for Eye Microsurgery, Tashkent, Uzbekistan

DOI:

https://doi.org/10.31288/oftalmolzh202432832

Keywords:

аge-related macular degeneration, neovascularization, optical coherence tomography, brolucizumab, intravitreal injection

Abstract

Aim. To evaluate the short-term efficacy of using a monoclonal antibody fragment (Brolucizumab) for treating neovascular age-related macular degeneration, depending on the morphometric parameters of the retina.

Methods: This study included 48 patients (60 eyes) diagnosed with neovascular age-related macular degeneration (nAMD). The observation period was 6 months. Brolucizumab was administered intravitreally at a dose of 6 mg (0.05 ml, 120 mg/ ml) once a month consistently for 3-4 months. Depending on the morphometric parameters, the retina patients were divided into three main groups.

Results: A pronounced clinical and morphological response was achieved after the first injection of Brolucizumab, and positive dynamics were observed throughout the entire observation period.

Conclusions: The use of the drug Brolucizumab significantly improves the visual functions of patients with neovascular AMD, as well as the morphological state of the retina in short-term follow-up, regardless of the initial morphometric characteristics of the retina, which allows not only to maintain but also to improve visual acuity and prevent blindness and visual disability in patients.

References

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Published

2024-07-02

How to Cite

1.
Yusupov AF, Karimova MK, Djamalova SA, Makhkamova DK, Abdullaeva SI, Zakirkhodjaeva MA, Khodjaeva ZA, Rakhimova DA. The Short-term efficacy of a monoclonal antibody fragment (brolucizumab) for treating neovascular age-related macular degeneration. J.ophthalmol. (Ukraine) [Internet]. 2024 Jul. 2 [cited 2024 Jul. 18];(3):28-32. Available from: https://ua.ozhurnal.com/index.php/files/article/view/130

Issue

Section

Clinical Ophthalmology