EPIDEMIOLOGICAL AND CLINICAL-FUNCTIONAL ASPECTS OF THE COMBINED COURSE OF AGE-RELATED MACULAR DEGENERATION AND PRIMARY GLAUCOMA
DOI:
https://doi.org/10.31288/oftalmolzh2023338Keywords:
age-related macular degeneration, primary glaucoma, geographic atrophyAbstract
Relevance. Age-related macular degeneration (AMD) and glaucoma are currently the main causes of irreversible vision loss in developed countries.
Purpose. To study the epidemiological and clinical-functional aspects of the combined course of age-related macular degeneration and primary glaucoma and to assess the quality of life of these patients.
Material and Methods. The analysis of 5,000 outpatient records of patients over 35 years of age who were observed in the consultative polyclinic of the multidisciplinary clinic of the Tashkent Medical Academy in the period 2011-2022 was carried out. All patients were divided into three groups: group 1 - glaucoma, group 2 - AMD, group 3 - glaucoma + AMD.
Results. A retrospective analysis of 5,000 outpatient records of patients older than 35 years revealed the presence of glaucoma in 30.3% of cases, AMD - in 37.94%, their combination - in 20.3%. At the same time, in the structure of AMD, signs of the dry form of the disease were diagnosed in 74% of cases, geographical atrophy - in 12% and wet form - in 14%. However, it requires careful monitoring of the dynamics of visual-functional and structural changes in the retina and optic nerve, as well as timely correction of therapy.
Conclusion. The combined course of diseases having a neurodegenerative nature of the lesion leads to a decrease in not only visual, but also cognitive functions, significantly affects the quality of life of patients of the older age group and their adaptation in society.
References
Akhmedov D, Kuchera T. Uzbekistan Population Forecast 2018-50. UNFPA in Uzbekistan: Prague-Tashkent. 2019. 63. [Available from: https://uzbekistan.unfpa]. org/sites/default/files/pubpdf/Population%20forecast%202018-2050.pdf]. Russian.
Demographic situation // Department of Statistics of Demography and Labor of Uzbekistan. [Available from: https://stat.uz/uploads/docs/demog-yan-dek-ru18.pdf]. Russian.
Tuychibayeva DM, Rizayev ZhA, Stozharova NK. Longitudinal changes in the incidence of glaucoma in Uzbekistan. J. ophthalmol. (Ukraine). 2021; 4:43-7.https://doi.org/10.31288/oftalmolzh202144347
Tuychibaeva DM. Longitudinal changes in the disability due to glaucoma in Uzbekistan. J. ophthalmol. (Ukraine). 2022;4:12-17.
https://doi.org/10.31288/oftalmolzh202241217
Hochberg C, Maul E, Chan ES, Van Landingham S, Ferrucci L, Friedman DS, Ramulu PY. Association of vision loss in glaucoma and age-related macular degeneration with IADL disability. Invest. Ophthalmol. Vis. Sci. 2012. 53. (6). 32-38. https://doi.org/10.1167/iovs.12-9469
Umfress A, Brantley M. Eye care disparities and health-related consequences in elderly patients with age-related eye disease. Semin. Ophthalmol. 2016. 31. (4). 432-438. https://doi.org/10.3109/08820538.2016.1154171
Wong W, Su X, Li X, Cheung CM, Klein R, Cheng CY, Wong TY. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob. Health. 2014. 2. (2). e106-e 116. https://doi.org/10.1016/S2214-109X(13)70145-1
Prokofyeva E, Zrenner E. Epidemiology of major eye diseases leading to blindness in Europe: A literature review. Ophthalmic Res. 2012. 47. (4). 171-188. https://doi.org/10.1159/000329603
Neroev VV. Visual disability in the Russian Federation // Russian Ophthalmological Congress "White Nights": abstract, May 28-30, 2017 St. Petersburg, 2017. [Available from: http:// glaucoma.eye-portal.ru/neroev-vv-disability-in-sight-in-russian-federation. pdf]. Russian.
Statistics: Life expectancy in Russia. [Available from: https://ruxpert.ru/ Statistics: Life expectancy in Russia]. Russian.
Krueger D, Milton R, Maunder L. The Framingham eye study: Introduction to the monograph. Surv. Ophthalmol. 1980. 24. (6). 614-620. https://doi.org/10.1016/0039-6257(80)90122-8
Tuychibaeva D, Rizaev J, Malinouskaya I. Dynamics of primary and general incidence due to glaucoma among the adult population of Uzbekistan. Ophthalmology. Vostochnaya Yevropa. 2021;11.1:27-38. https://doi.org/10.34883/PI.2021.11.1.003
Tuychibaeva DM. Main Characteristics of the Dynamics of Disability Due to Glaucoma in Uzbekistan. Ophthalmology. Eastern Europe, 2022;12.2:195-204. https://doi.org/10.34883/PI.2022.12.2.027
Rizaev J, Tuychibaeva D. Incidence rates of glaucoma among the adults republic of Uzbekistan. Stomatologiya. 2021;1(82):102-107. [Russian]
Rizaev J, Tuychibaeva D. Study of the general state and dynamics of primary and general disability due to glaucoma of the adults in the republic of Uzbekistan and the city of Tashkent. Journal of Dentistry and Craniofacial Research. 2022;1(2):75-77.
Rizayev J, Tuychibaeva D. Forecasting the incidence and prevalence of glaucoma in the Republic of Uzbekistan. Journal of Biomedicine and Practice. 2020;6(5):180-186. [Russian].
Cuellar-Partida G, Craig J, Burdon KP, Wang JJ, Vote BJ, Souzeau E et al. Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration // Sci. Rep. 2016; 6: 26885. https://doi.org/10.1038/srep26885
Feigl B. Age-related maculopathy - Linking aetiology and pathophysiological changes to the ischaemia hypothesis. Prog. Retin. Eye Res. 2009. 28. (1). 63-86. https://doi.org/10.1016/j.preteyeres.2008.11.004
Garner A, Sarks A, Sarks JP. Degenerative and related disorders of the retina and choroids. Pathobiology of ocular disease, 2nd ed. / Ed. M. Dekker. N.Y., 1994. 631-674.
Morgan J. Optic nerve head structure in glaucoma: Astrocytes as mediators of axonal damage. Eye. 2000. 14. (3b). 437-444. https://doi.org/10.1038/eye.2000.128
Hu C, Ho J, Lin H, Kao L. Association between open-angle glaucoma and neovascular age-related macular degeneration: a case-control study. Eye. 2017. 31. (6). 872-877. https://doi.org/10.1038/eye.2016.325
Kashiwagi K, Iizuka Y, Tanaka Y, Araie M, Suzuki Y, Tsukahara S. Molecular and cellular reactions of retinal ganglion cells and retinal glial cells under centrifugal force loading. Invest. Ophthalmol. Vis. Sci. 2004. 45. (10). 3778-3786. https://doi.org/10.1167/iovs.04-0277
Masuzzo A, Dinet V, Cavanagh C, Mascarelli F, Krantic S. Amyloidosis in retinal neuro-degenerative diseases. Front. Neurol. 2016. 7. 127. https://doi.org/10.3389/fneur.2016.00127
Medeiros NE, Curcio CA. Preservation of ganglion cell layer neurons in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2001. 42. (3). 795-803.
Remsch H, Spraul C, Lang G, Lang G. Changes of retinal capillary blood flow in age-related maculopathy. Graefe's Arch. Clin. Exp. Ophthalmol. 2000. 238. (12). 960-964. https://doi.org/10.1007/s004170000202
Coleman DJ, Silverman RH, Rondeau MJ, Lloyd HO, Khanifar AA, Chan RV. Age-related macular degeneration: choroidal ischaemia. Br. J. Ophthalmol. 2013. 97. (8). 1020-1029. https://doi.org/10.1136/bjophthalmol-2013-303143
Dusmukhamedova AM, Tuychibaeva DM, Khadzhimetov AA. Assessing factors of endothelial vascular dysfunction in patients with primary open-angle glaucoma. J.ophthalmol. (Ukraine). 2022;6:14-18. https://doi.org/10.31288/oftalmolzh202261418
Rimayanti U, Kiuchi Y, Yamane K. et al. Inner retinal layer comparisons of eyes with exudative age-related macular degeneration and eyes with age-related macular degeneration and glaucoma. Graefe's Arch. Clin. Exp. Ophthalmol. 2013. 252. (4). 563-570. https://doi.org/10.1007/s00417-013-2496-z
Coscas G, de Benedetto U, Coscas F, Li Calzi CI, Vismara S, Roudot-Thoraval F. et al. Hyperreflective dots: a new spectral-domain optical coherence tomography entity for follow-up and prognosis in exudative age-related macular degeneration. Ophthalmologica. 2013. 229. (1). 32-37. https://doi.org/10.1159/000342159
Tan O, Chopra V, Lu AT, Schuman JS, Ishikawa H, Wollstein G et al. Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography. Ophthalmology. 2009. 116. (12). 2305-2314. https://doi.org/10.1016/j.ophtha.2009.05.025
Velpandian T, Nath M, Halder N. Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy. Indian J. Ophthalmol. 2017. 65. (3). 191-198. https://doi.org/10.4103/ijo.IJO_866_16
Zucchiatti I, Parodi M, Pierro L, Cicinelli MV, Gagliardi M, Castellino N, Bandello F. Macular ganglion cell complex and retinal nerve fiber layer comparison in different stages of age-related macular degeneration. Am. J. Ophthalmol. 2015. 160. (3). 602-607. https://doi.org/10.1016/j.ajo.2015.05.030
Prins D, Hanekamp S, Cornelissen F. Structural brain MRI studies in eye diseases: are they clinically relevant. A review of current findings. Acta Ophthalmol. 2015. 94. (2). 113-121. https://doi.org/10.1111/aos.12825
Harrabi H, Kergoat MJ, Rousseau J, Boisjoly H, Schmaltz H, Moghadaszadeh S et al. Age-related eye disease and cognitive function. Invest. Ophthalmol. Vis. Sci. 2015. 56. (2). 1217-1221. https://doi.org/10.1167/iovs.14-15370
Zheng Y, Wu X, Lin X, Lin H. The prevalence of depression and depressive symptoms among eye disease patients: A systematic review and meta-analysis. Sci. Rep. 2017. 7. 453-464. https://doi.org/10.1038/srep46453
Novik AA, Ionova TI. Guidelines for the study of quality of life in medicine. 2nd ed. M.: OLMA Media group, 2007. 320 p.
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