Histomorphology of the healthy fellow eye in the rabbit with unilaterally induced non-infectious anterior and intermediate uveitis
DOI:
https://doi.org/10.31288/oftalmolzh202044549Keywords:
non-infectious anterior uveitis, non-infectious intermediate uveitis, ocular surface temperature, histomorphological statusAbstract
Background: It is important to use objective methods for assessing intraocular inflammation in the practical management of uveitis. Previously, we have found that, on day 1 of unilaterally induced non-infectious anterior and intermediate uveitis in rabbits, the temperature in ciliary body projection onto the ocular surface increased to 35.7°С (р = 0.002) for the challenged eyes and to 35.0°С (р=0.05) for the fellow eyes compared to eyes of intact rabbits (34.1°С).
Purpose: To assess the histomorphology of the healthy fellow eye in rabbits with unilaterally induced non-infectious anterior and intermediate uveitis.
Material and Methods: Seventeen Chinchilla rabbits (34 eyes; weight, 2.5-3.0 kg) were included in this study. Non-infectious anterior or intermediate uveitis was induced in the right eye of each rabbit, while the left was intact. Histomorphological studies of the fellow eyes were performed at various time points after challenge.
Results: The fellow eyes showed normal histomorphology.
Conclusion: A significant increase in the temperature in ciliary body projection onto the ocular surface to 35.0°С (р=0.05) for the fellow eyes compared to eyes of intact rabbits on day 1 of induced non-infectious anterior and intermediate uveitis in rabbits was not accompanied by any histomorphological or pathological changes, and was functional in nature.
References
1.Acharya NR, Tham VM, Esterberg E, et al. Incidence and prevalence of uveitis: results from the Pacific Ocular Inflammation Study. JAMA Ophthalmol. 2013 Nov;131(11):1405-12. https://doi.org/10.1001/jamaophthalmol.2013.4237
2.Bodaghi B, Cassoux N, Wechsler B, et al. Chronic severe uveitis: etiology and visual outcome in 927 patients from a single center. Medicine (Baltimore). 2001 Jul;80(4):263-70.https://doi.org/10.1097/00005792-200107000-00005
3.Nussenblatt RB. The natural history of uveitis. Int Ophthalmol. 1990;14:303-8.https://doi.org/10.1007/BF00163549
4.Suttorp-Schulten MS, Rothova A. The possible impact of uveitis in blindness: a literature survey. Br J Ophthalmol. 1996 Sep; 80(9): 844-8.https://doi.org/10.1136/bjo.80.9.844
5.Barisani-Asenbauer T, Maca SM, Mejdoubi L, Emminger W, Machold K, Auer H. Uveitis- a rare disease often associated with systemic diseases and infections- a systematic review of 2619 patients. Orphanet J Rare Dis. 2012 Aug 29;7:57.https://doi.org/10.1186/1750-1172-7-57
6.Astakhov IuS, Kuztetsova TI. [Laser flare photometry in clinical practice]. Oftalmologicheskie vedomosti. 2016;9(2):36-44. Russian.https://doi.org/10.17816/OV9236-44
7.Guney E, Tugal-Tutkun I. Symptoms and Signs of Anterior Uveitis. US Ophthalmic Rev. 2013;6(1):33-7.https://doi.org/10.17925/USOR.2013.06.01.33
8.Herbort CP, Guex-Crosier Y, de Ancos E, et al. Use of laser flare photometry to assess and monitor inflammation in uveitis. Ophthalmology. 1997 Jan;104(1):64-71.https://doi.org/10.1016/S0161-6420(97)30359-5
9.Ladas JG, Wheeler NC, Morhun PJ, et al. Laser flare-cell photometry: methodology and clinical applications. Surv Ophthalmol. Jan-Feb 2005;50(1):27-47.https://doi.org/10.1016/j.survophthal.2004.10.004
10.Tugal-Tutkun I, Herbort CP. Laser flare photometry: a noninvasive, objective, and quantitative method to measure intraocular inflammation. Int Ophthalmol. 2010;30:453-64.https://doi.org/10.1007/s10792-009-9310-2
11.Wakefield D, Herbort CP, Tugal-Tutkun I, Zierhut M. Controversies in ocular inflammation and immunology laser flare photometry. Ocul Immunol Inflamm. 2010 Oct;18(5):334-40.https://doi.org/10.3109/09273948.2010.512994
12.Vinogradov VI, Veretenov IS, Slezko VN, Pugach GI, Landa VA, Bol'shakova GI. [Some aspects of application of thermography in the rehabilitation of patients with dysfunction of the musculoskeletal and nervous systems]. Funktsionalnaia diagnostika. 2005;3:72-8. Russian.
13.Zabolotnyi DI, Rozenfeld LG, Kolotilov NN, et al. [Novel potential of infrared thermography in otolaryngology]. Zhurnal vushnykh, nosovykh i gorlovykh khvorob. 2005;5:2-5. Russian.https://doi.org/10.3166/qirt.2.5-24
14.Zamechnik TV, Larin SI. [The potential of thermography in diagnosing varicose veins of the lower extremities]. Flebologiia. 2009;3:10-14. Russian.
15.Lakusta VN, Moraru AT. [Thermography and cryotherapy in ortopedic neurology]. Kishinev; 2005. Russian.
16.Markel AL, Vainer BG. [Infrared thermography in the diagnosis of breast cancer: review of foreign literature]. Terapevticheskii Arkhiv. 2005;77:57-61. Russian.
17.Yakupov AF, Anisimov AIu, Galimzyanov AF, et al. [The potential of thermography in diagnosing and treating patients with portal hypertension-associated hepatic cirrhosis]. Kazanskii meditsinskii zhurnal. 2008;89(6):842-6. Russian.
18.Berry RJ, Kennedy AD, Scott SL, Kyle BL, Schaefer AL. Daily variation in the udder surface temperature of dairy cows measured by infrared thermography: Potential for mastitis detection. Can J Anim Sci. 2003;83:687-93.https://doi.org/10.4141/A03-012
19.Chidambaram R, Shrinuvasan S, Srikumar R, et al. Digital infrared thermal imaging: as adjuvant screening modality in medical specialties. Journal of Innovative Research and Solutions (JIRAS). 2015; 1(1):13-9.
20.Hildebrandt C, Raschner C, Ammer K. An overview of recent application of medical infrared thermography in sports medicine in Austria. Sensors (Basel). 2010;10(5):4700-15.https://doi.org/10.3390/s100504700
21.Kaczmarek M, Nowakowski A, Siebert J, et al. Infrared thermography: applications in heart surgery. Proc SPIE. 1999;3730:184-8.https://doi.org/10.1117/12.346861
22.Lahiri BB, Bagavathiappan S, Jayakumar T, et al. Medical applications of infrared thermography: a review. Infrared Phys Technol. 2012 Jul; 55(4): 221-35.https://doi.org/10.1016/j.infrared.2012.03.007
23.Ng EY. A review of thermography as promising non-invasive detection modality for breast tumor. Int J Therm Sci. 2009;48:849-59.https://doi.org/10.1016/j.ijthermalsci.2008.06.015
24.Ring EF. The historical development of thermometry and thermal imaging in medicine. J Med Eng Technol. Jul-Aug 2006;30(4):192-8.https://doi.org/10.1080/03091900600711332
25.Soffin CB, Morse DR, Seltzer S, et al. Thermography and oral inflammatory conditions . Oral Surg Oral Med Oral Pathol. 1983 Sep;56(3):256-62.https://doi.org/10.1016/0030-4220(83)90006-3
26.Dorokhova O, Zborovska O, Meng Guanjun, et al. Temperature of the ocular surface in the projection of the ciliary body in rabbits. J Ophthalmol (Ukraine). 2020;2(493):65-9.https://doi.org/10.31288/oftalmolzh202026569
27.Dorokhova O, Zborovska O, Meng Guanjun. Temperature of the ocular surface in the projection of the ciliary body early in induced non-infectious uveitis in rabbits. J Ophthalmol (Ukraine). 2020;3(494):47-52.https://doi.org/10.31288/oftalmolzh202034752
28.Chernookova VA. [Clinical and functional patterns of oculo-ocular reflexes in unilateral mechanical ocular trauma]. [Abstract of a Thesis for the Degree of Cand Sc (Med)]. Moscow: Moscow Helmholtz Research Institute for Eye Diseases; 2007. Russian.
29.Chu XK, Chan CC. Sympathetic ophthalmia: to the twenty-first century and beyond. J Ophthalmic Inflamm Infect. 2013 Jun 1;3(1):49.https://doi.org/10.1186/1869-5760-3-49
30.Lopatinskaia NR. [Remote thermography and pupil response analysis the diagnosis of primary open-angle glaucoma]. [Abstract of a Thesis for the Degree of Cand Sc (Med)]. Saratov: Saratov State Medical University; 2012. Russian.
31.Chen J, Caspi RR. Clinical and Functional Evaluation of Ocular Inflammatory Disease Using the Model of Experimental Autoimmune Uveitis. Methods Mol Biol. 2019;1899:211-227.https://doi.org/10.1007/978-1-4939-8938-6_15
32.BenEzra D, Cohen E, Maftzir G. Uveitis in children and adolescents. Br J Ophthalmol. 2005 Apr;89(4):444-8.https://doi.org/10.1136/bjo.2004.050609
33.Hogan MJ, Kimura SJ, Thygeson P. Signs and symptoms of uveitis. I. Anterior uveitis. Am J Ophthalmol. 1959 May;47(5 Pt 2):155-70.https://doi.org/10.1016/S0002-9394(14)78239-X
34.Mahabadi N, Kim J, Edens MA. Iritis. 2019 Jun 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK430909/
35.Smith JR, Rosenbaum JT. Management of uveitis: A rheumatologic perspective. Arthritis Rheum. 2002 Feb;46(2):309-18.https://doi.org/10.1002/art.503
36.Acharya UR, Tan JH, Koh JE, et al. Automated diagnosis of dry eye using infrared thermography images. Infrared Phys Technol. 2015; 71:263-71.https://doi.org/10.1016/j.infrared.2015.04.007
37.Craig JP, Singh I, Tomlinson A. The role of tear physiology in ocular surface temperature. Eye. Eye (Lond). 2000 Aug;14 (Pt 4):635-41.https://doi.org/10.1038/eye.2000.156
38.Morgan PB, Tullo AB, Efron N. Infrared thermography of the tear film in dry eye. Eye (Lond). 1995;9 ( Pt 5):615-8.https://doi.org/10.1038/eye.1995.149
39.Tan J-H, Ng EYK, Acharya UR. Evaluation of tear evaporation from ocular surface by functional infrared thermography. Med Phys. 2010 Nov;37(11):6022-34. https://doi.org/10.1118/1.3495540
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