Efficacy of a combination of conservative and surgical methods of treatment for neovaascular glaucoma associated with diabetic retinopathy and central or branch retinal vein occlusion

Authors

DOI:

https://doi.org/10.31288/oftalmolzh202431623

Keywords:

secondary neovascular glaucoma, retinal laser photocoagulation, intravitreal anti-VEGF injection, ranibizumab, glaucoma surgery, intraocular pressure

Abstract

Background: Neovascular glaucoma (NVG) is secondary glaucoma which is often resistant to medical therapy and may potentially lead to blindness.

Purpose: To assess the efficacy of a combination of conservative and surgical methods of treatment for NVG associated with proliferative diabetic retinopathy (PDR) and central or branch retinal vein occlusion (CRVO or BRVO).

Material and Methods: Fifty-six patients (68 eyes) with NVG were under our observation. These included 48 patients (60 eyes) with NVG associated with PDR and 8 patients (8 eyes) with NVG associated with CRVO or BRVO. The mean patient age was 64.0 ± 10.0 years. Group 1 (22 patients, 33 eyes) received hypotensive ocular hypotensive medication, retinal laser photocoagulation and intravitreal ranibizumab. In addition to the above treatment, group 2 (34 patients, 35 eyes) received filtration surgery. Of the 68 eyes, 24 received single ranibizumab 0.5 mg injection; 26 eyes, two to four injections, and 18 eyes, five or more injections.

Results: The treatment resulted in a partial reduction in iris neovascularization in 53/68 eyes, and total reduction, in 15/68 eyes. In a total sample of patients, the IOP reduced from 29.1 ± 7.9 mmHg at baseline to 20.4 ± 4.8 mmHg after treatment, and the mean number of IOP-lowering medications, from 2.1 ± 1.1 at baseline to 0.9 ± 0.9 after treatment.

Conclusion: The combination treatment for NVG was found to enable an IOP reduction of 29.9% and prevent a significant reduction in visual acuity in 85% of eyes with NVG.

Author Biographies

U. P. Sydorchuk, Danylo Halytsky Lviv National Medical University

Post-Graduate Student at Ophthalmology Department, Faculty of Post-Graduate Education, Danylo Halytsky Lviv National Medical University and Ophthalmologist at Oculus Medical Center

I. Ia. Novytskyy, Danylo Halytsky Lviv National Medical University and Oculus Medical Center

Dr Sc (Med), Prof. at Ophthalmology Department, Faculty of Post-Graduate Education, Danylo Halytsky Lviv National Medical University and Oculus Medical Center

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Published

2024-07-02

How to Cite

1.
Sydorchuk UP, Novytskyy II. Efficacy of a combination of conservative and surgical methods of treatment for neovaascular glaucoma associated with diabetic retinopathy and central or branch retinal vein occlusion. J.ophthalmol. (Ukraine) [Internet]. 2024 Jul. 2 [cited 2024 Jul. 18];(3):16-23. Available from: https://ua.ozhurnal.com/index.php/files/article/view/139

Issue

Section

Clinical Ophthalmology