Neutrophil activation marker CD15+ as a prognostic factor of ocular surface damage in type 2 diabetics
DOI:
https://doi.org/10.31288/oftalmolzh202411519Keywords:
cornea, ocular surface, neutrophil activation marker CD15 , type 2 diabetes, prognosisAbstract
Purpose: To evaluate the prognostic value of the neutrophil activation marker CD15+ in ocular surface damage in type 2 diabetics.
Material and Methods: This study was conducted from January 2021 to January 2021 at the Pirogov Vinnytsia Regional Clinical Hospital, the clinical site of the Medical University. A total of 60 type 2 diabetics (120 eyes) were enrolled, with an average age of 62.1 ± 5.24 years.
Results: The prognostic value of the percentage expression of CD15+ in ocular surface damage in type 2 diabetics was for the first time evaluated. A rather high sensitivity of the percentage expression of CD15 (88.3%) allows using it as a parameter for screening for the presence of ocular surface damage in type 2 diabetics. Type 2 diabetics with a percentage of >27% of CD15+ cells had 10.52 times increased odds of ocular surface damage (95%CI, 4.34–25.50; p < 0.0001), and this value of the percentage of CD15+ cells can be used for the purpose of screening for ocular surface damage with a sensitivity of 88.3% (95% СІ, 77.8-94.2) and specificity of 63.3% (95% СІ, 50.7-74.4).
References
Shih K, Lam KL, Tong L. A systematic review on the impact of diabetes mellitus on the ocular surface. Nutr Diabetes. 2017 Mar 20;7(3):e251. https://doi.org/10.1038/nutd.2017.4
Lin X, Xu B, Zheng Y, Coursey TG, Zhao Y, Li J, et al. Meibomian Gland Dysfunction in Type 2 Diabetic Patients. J Ophthalmol. 2017;2017:3047867. https://doi.org/10.1155/2017/3047867
Szlasa W, Wilk K, Knecht-Gurwin K, Gurwin A, Froń A, Sauer N, et al. Prognostic and Therapeutic Role of CD15 and CD15s in Cancer. Cancers (Basel). 2022 Apr 28;14(9):2203. https://doi.org/10.3390/cancers14092203
Nakayama F, Nishihara S, Iwasaki H, Kudo T, Okubo R, Kaneko M, et al. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. J Biol Chem. 2001; 276(19):16100-6. https://doi.org/10.1074/jbc.M007272200
Gadhoum SZ, Sackstein R. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity. Nat Chem Biol. 2008;4(12):751-7. https://doi.org/10.1038/nchembio.116
Oh EJ, Bychkov A, Cho H, Kim TM, Bae JS, Lim DJ, Jung CK. Prognostic Implications of CD10 and CD15 Expression in Papillary Thyroid Carcinoma. Cancers (Basel). 2020;12(6):1413. https://doi.org/10.3390/cancers12061413
O'Rourke M, Fearon U, Sweeney CM, Basdeo SA, Fletcher JM, Murphy CC, Canavan M. The pathogenic role of dendritic cells in non-infectious anterior uveitis. Exp Eye Res. 2018 Aug:173:121-8. https://doi.org/10.1016/j.exer.2018.05.008
Mun Y, Hwang JS, Shin YJ. Role of Neutrophils on the Ocular Surface. Int J Mol Sci. 2021; 22(19): 10386. https://doi.org/10.3390/ijms221910386
Lahoz-Beneytez J, Elemans M, Zhang Y, et al. Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives. Blood. 2016;127(26):3431-8. https://doi.org/10.1182/blood-2016-03-700336
Stevenson W, Chauhan SK, Dana R. Dry eye disease: an immune-mediated ocular surface disorder. Arch Ophthalmol. 2012 Jan;130(1):90-100. https://doi.org/10.1001/archophthalmol.2011.364
Yu Y, Sun B. Autophagy-mediated regulation of neutrophils and clinical applications. Burns Trauma. 2020 Jan 16:8:tkz001. https://doi.org/10.1093/burnst/tkz001
Gorbet M, Postnikoff C, Williams S. The Noninflammatory Phenotype of Neutrophils From the Closed-Eye Environment: A Flow Cytometry Analysis of Receptor Expression. Invest Ophthalmol Vis Sci. 2015;56(8):4582-4591. https://doi.org/10.1167/iovs.14-15750
Nelson JD, Wright JC. Conjunctival Goblet Cell Densities in Ocular Surface Disease. Arch Ophthalmol. 1984;102(7):1049-51. https://doi.org/10.1001/archopht.1984.01040030851031
Zhmud TM, Velychko LM, Drozhzhyna GI, Bogdanova OV. Percentage expression of neutrophil activation marker in the peripheral blood of patients with dry eye disease plus type 2 diabetes. J Ophthalmol (Ukraine). 2022;1:24-29. https://doi.org/10.31288/oftalmolzh202212429
Zhmud T, Drozhzhyna G, Malachkova N. Evaluation and comparison of subjective and objective anterior ocular surface damage in patients with type 2 diabetes mellitus and dry eye disease. Graefes Arch Clin Exp Ophthalmol. 2023 Feb;261(2):447-52. https://doi.org/10.1007/s00417-022-05806-3
Zhmud TM, Drozhzhyna GI, Demchuk AV. Cytological features of the bulbar conjunctiva in patients with type 2 diabetes mellitus. J Ophthalmol (Ukraine). 2022;1:84-8. https://doi.org/10.31288/oftalmolzh202218488
Sergeant ESG, 2018. Epitools Epidemiological Calculators. Ausvet. Available at: http://epitools.ausvet.com.au.
Rolando M, Barabino S, Giannaccare G, Aragona P. Dealing with the Persistent Pathogenic Issues of Dry Eye Disease: The Importance of External and Internal Stimuli and Tissue Responses. J Clin Med. 2023 Mar 13;12(6):2205. https://doi.org/10.3390/jcm12062205
Postnikoff CK, Huisingh C, McGwin G, Nichols KK. Leukocyte Distribution in the Open Eye Tears of Normal and Dry Eye Subjects. Curr Eye Res. 2018 Oct;43(10):1253-9. 2018;43(10):1253-9. https://doi.org/10.1080/02713683.2018.1500611
Sambursky R, Davitt WF, Latkany R, et al. Sensitivity and Specificity of a Point-of-Care Matrix Metalloproteinase 9 Immunoassay for Diagnosing Inflammation Related to Dry Eye. JAMA Ophthalmol. 2013;131(1):24-28. https://doi.org/10.1001/jamaophthalmol.2013.561
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Zhmud T. M., Drozhzhyna G. I., Velychko L. M.
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.
