Cytological conjunctival changes in patients with type 2 diabetes-associated dry eye in the presence of treatment with a combination of trehalose plus sodium hyaluronate

Authors

  • T.M. Zhmud National Pirogov Memorial Medical University, Vinnytsia https://orcid.org/0000-0002-9306-8674
  • G.I. Drozhzhyna SI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine"

DOI:

https://doi.org/10.31288/oftalmolzh2024337

Keywords:

trehalose, T2DM, dry eye disease, impression cytology, inflammatory infiltration, ocular surface, cornea

Abstract

Purpose: To assess cytological conjunctival changes in patients with type 2 diabetes mellitus (T2DM)-associated dry eye disease in the presence of treatment with a combination of trehalose and sodium hyaluronate.

Material and Methods: This study was conducted at the Pirogov Vinnytsia Regional Clinical Hospital, the clinical site of the National Pirogov Memorial Medical University, from April to December 2023. We used prospective data of 46 patients (92 eyes; mean age, 62.47 ± 6.24 years).

Results: Most patients (67%) showed abnormal conjunctival impression cytology (CIC) changes (Nelson’s grade 2 and 3) before treatment.  Among these, grade 3 squamous metaplasia was twice as common as grade 2 squamous metaplasia; this demonstrated apparent CIC changes in the group of patients, and a substantial prevalence of squamous metaplasia in type 2 diabetics. After treatment with a combination of trehalose 3% plus sodium hyaluronate 0.15%, neutrophil infiltration was observed only in 5 (11%) patients (р = 0.0375), which may indicate an anti-inflammatory effect of the combination.

Conclusion: We found a significant effect of a combination of trehalose 3% plus sodium hyaluronate 0.15% on the state of the ocular surface, with the resolution of inflammatory conjunctival infiltration, in patients with T2DM (p = 0.0375). Because stabilization or slowing of damage to epithelial cells is important for patients with T2DM and was observed in the presence of treatment with the combination eye drop, these patients require long-term treatment with the medication.

Author Biographies

T.M. Zhmud, National Pirogov Memorial Medical University, Vinnytsia

Cand Sc (Med), and Assistant Professor, Eye Disease Department, National Pirogov Memorial Medical University, Vinnytsia

G.I. Drozhzhyna, SI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine"

Dr Sc (Med), Professor, and Chief, Corneal Pathology Department, SI “The Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine”

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Published

2024-07-02

How to Cite

1.
Zhmud T, Drozhzhyna G. Cytological conjunctival changes in patients with type 2 diabetes-associated dry eye in the presence of treatment with a combination of trehalose plus sodium hyaluronate. J.ophthalmol. (Ukraine) [Internet]. 2024 Jul. 2 [cited 2024 Jul. 3];(3):3-7. Available from: https://ua.ozhurnal.com/index.php/files/article/view/145

Issue

No. 3 (2024): Journal of Ophthalmology (Ukraine)

Section

Clinical Ophthalmology

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Copyright (c) 2024 Zhmud T.M., Drozhzhyna G.I.

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