On the possibility of neoplastic growth of the descemet's corneal endothelium

Authors

  • A. V. Artemov SI "The Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine", Odessa, Ukraine
  • M. V. Lytvynenko Odessa National Medical University, Odessa, Ukraine
  • L. Y. Kovalchuk International Humanitarian University, Odesa, Ukraine
  • L. M. Larson Odessa National Medical University, Odessa, Ukraine
  • S. G. Kotiuzhynska Odessa National Medical University, Odessa, Ukraine
  • S. O. Chebotarova Odessa National Medical University, Odessa, Ukraine
  • O. L. Koshelnyk Odessa National Medical University, Odessa, Ukraine
  • I. M. Petrusenko Odessa National Medical University, Odessa, Ukraine
  • V. V. Gargin Kharkiv National Medical University, Kharkiv International Medical University, Kharkiv, Ukraine
  • V. Ie. Lunov Bogomolets National Medical University, Kyiv, Ukraine

DOI:

https://doi.org/10.31288/Ukr.j.ophthalmol.202613439

Keywords:

posterior corneal epithelium, neoplastic proliferation, intraocular tumors, cornea

Abstract

Background: The tumor process inside the eye covers most of the inner perimeter: from the iris to the optic nerve head. At the same time, there is a little information about neoplastic changes of Descemet’s endothelium although the cells of this tissue prone to proliferation and pathological tissue growths.
Aim: To present a histomorphological picture of unusual proliferation of the Descemet's endothelium, which had some signs of a neoplasm.
Materials and Methods: The histomorphological picture of a unique pathological process was studied in 40 serial sections of the eyeball. The histological picture was compared with the clinical one.
Results: Histomorphological examination revealed obliteration of the iridocorneal angle with fibrosis-hyalinosis of the drainage zone and neoplastic changes inside the eye: a cavernous hemangioma, neoplastic complexes of flattened round-oval non-pigmented cells in the zonule of Zinn, in the anterior chamber, on the anterior surface of the iris and identical cell complexes along the surface of Descemet's membrane.
Conclusions: For the first time, emphasis was placed on the possibility of a neoplastic process in the endothelium of Descemet's membrane, the implementation of which is extremely difficult due to the absence of a stromal-vascular pool in this tissue system.

Author Biographies

A. V. Artemov, SI "The Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine", Odessa, Ukraine

Artemov A.V., Head of the Laboratory of Pathomorphological and Electron Microscopy Research, SI «The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine» 49/51, French bulvar, Odessa, Ukraine, 61061.

M. V. Lytvynenko, Odessa National Medical University, Odessa, Ukraine

Lytvynenko M.V. – Candidate of Medical Sciences, Associate Professor of the Department of Histology, Сytology, Еmbryology and Pathological Morphology with a Course of Forensic Medicine, «Odessa National Medical University». 2, Valikhovsky lane, Odessa, Ukraine, 65082.

L. Y. Kovalchuk, International Humanitarian University, Odesa, Ukraine

Kovalchuk L. Y. - Doctor of Medical Sciences, Associate Professor, Professor of the Department, Head of the Department of General Medical Sciences of the «International Humanitarian University» 33, Fontanska road, Odessa, Ukraine, 65000.

L. M. Larson, Odessa National Medical University, Odessa, Ukraine

Larson L.N. - assistant of the Department of Histology, Сytology, Еmbryology and Pathological Morphology with a Course of Forensic Medicine of «Odessa National Medical University». 2, Valikhovsky lane, Odessa, Ukraine, 65082.

S. G. Kotiuzhynska, Odessa National Medical University, Odessa, Ukraine

Kotiuzhynska S. G. – professor of the Department of General and Clinical Pathological Physiology named V.V. Pidvysotsky «Odessa National Medical University». 2, Valikhovsky lane, Odessa, Ukraine, 65082.

S. O. Chebotarova, Odessa National Medical University, Odessa, Ukraine

Chebotarova S.O. – senior lecturer of Department of Human Anatomy of «Odessa National Medical University». 2, Valikhovsky lane, Odessa, Ukraine, 65082.

O. L. Koshelnyk, Odessa National Medical University, Odessa, Ukraine

Koshelnyk O. L. - PhD, assistant professor of Department of Human Anatomy of «Odessa National Medical University». 2, Valikhovsky lane, Odessa, Ukraine, 65082.

I. M. Petrusenko, Odessa National Medical University, Odessa, Ukraine

Petrusenko I.N. - assistant of the Department of Histology, Сytology, Еmbryology and Pathological Morphology with a Course of Forensic Medicine of «Odessa National Medical University». 2, Valikhovsky lane, Odessa, Ukraine, 65082.

V. V. Gargin, Kharkiv National Medical University, Kharkiv International Medical University, Kharkiv, Ukraine

Gargin V. V. - Doctor of Medical Sciences, Professor, Professor of Department of Pathological Anatomy, Kharkiv National Medical University, Kharkiv, Ukraine, Department of Professionally Oriented Disciplines, 4 Nauky Avenue, Kharkiv, 61022, Ukraine.

V. Ie. Lunov, Bogomolets National Medical University, Kyiv, Ukraine

Lunov V. Ie. - Cand of Psych Sc., associate professor of the department of General and Medical Psychology.  Bogomolets National Medical University, Kyiv, Ukraine

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Published

2026-02-26

How to Cite

[1]
Artemov, A.V. et al. 2026. On the possibility of neoplastic growth of the descemet’s corneal endothelium. Ukrainian Journal of Ophthalmology . 1 (Feb. 2026), 34–39. DOI:https://doi.org/10.31288/Ukr.j.ophthalmol.202613439.

Issue

No. 1 (2026): Ukrainian Journal of Ophthalmology

Section

Clinical Ophthalmology

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Copyright (c) 2026 Artemov A. V., Lytvynenko М. V., Kovalchuk L. Y., Larson L. M., Kotiuzhynska S. G., Chebotarova S. O., Koshelnyk O. L., Petrusenko I. M., Gargin V. V., Lunyov V. Ie

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