Dynamics of immune response to exogenous Staphylococcus aureus endophthalmitis with using antibacterial photodynamic therapy with methelene blue and intravitreal antibiotic in a rabbit model
DOI:
https://doi.org/10.31288/oftalmolzh20141108113Keywords:
Staphylococcus aureus endophthalmitis, immune response, experiment, antibacterial photo-dynamic therapy, methylene blue, VancomycinAbstract
Introduction. It is necessary to study the influence of antibacterial photodynamic therapy (APDT) with 0.1 % methylene blue (MB) alone and in combination with intravitreal injection (IVI) of the antibiotic on the immune response to exogenous Staphylococcus aureus endophthalmitis.
Purpose: to make a comparative analysis of the dynamics of local and general immune response to exogenous Staphylococcus aureus endophthalmitis with using APDT with 0.1 % MB and IVI of 1.0 mg Vancomycin independently, as well as using these techniques in the complex.
Material and methods. In the experimental study four groups of rabbits are presented: I — without using any treatment, II — APDT with 0.1 % MB, III — IVI of 1.0 mg Vancomycin, IV — APDT with 0.1 % MB and IVI of 1.0 mg Vancomycin. Results: In the groups II and III dynamics of immune response did not differ, the normalization of the indices of immunity occurred at 21—30 days of the experiment, when the IV group of animals from the 10-day study.
Conclusions. Using of APDT with 0.1 % MB and IVI of 1.0 mg Vancomycin together led to normalization of immune status of rabbit and elimination from the inflammatory process autoimmune component from day 10. At the same time, using these methods separatly led to the same result, but only from the day 21.
References
1.Gluzman DF, Sklyarenko AM, Nagornaya VA. Diagnostic immunocytochemistry of tumors. K.:Morion; 2003. 136 p.
2.Degtyarenko TV. Adaptive significance of immune homeostasis in eye diseases. Oftalmol Zh. 1997;1:1-4.
3.Zborovskaya AV, Kustrin TB, Nasinnik IO. The experimental model of bacterial endophthalmitis. Oftalmol Zh. 2011;4:81-3.https://doi.org/10.31288/oftalmolzh201148183
4.Kulbaba OG. Changes in local immunity in the treatment of herpetic keratitis patients. Oftalmol Zh. 2007;6:42-5.
5.Malik Z, Ladan H, Nitzan Y, Smetana Z. Antimicrobal and antiviral activity of porphyrin photosensitation. Photodynamic therapy of cancer. 1994;305- 12.https://doi.org/10.1117/12.168668
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 О. В. Зборовська, Н. Б. Курильців
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.
