Antimicrobial effects of hydrogel implants incorporating gold nanoparticles and albucide and developed for reconstructive surgery in the orbit and periorbital area

Authors

  • Yu. M. Samchenko F.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of Ukraine
  • S. M. Dybkova F.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of Ukraine
  • Anatolii Maletskyi SI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine" https://orcid.org/0000-0002-7135-5218
  • L. O. Kernosenko F.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of Ukraine
  • T. G. Gruzina F.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of Ukraine
  • N. O. Pasmurtseva F.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of Ukraine
  • L. S. Rieznichenko F.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of Ukraine
  • O. B. Liutko SI “The Institute of Traumatology and Orthopedics” by NAMS of Ukraine"
  • K. V. Vitrak SI “The Institute of Traumatology and Orthopedics” by NAMS of Ukraine"
  • N. M. Bigun Lviv Regional Clinical Hospital
  • P. V. Vorotytskyi F.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of Ukraine
  • I. Ie. Mamyshev Institute of Geological Science of Ukraine National Science Academy

DOI:

https://doi.org/10.31288/oftalmolzh202352733

Keywords:

hydrogel implants containing Au nanoparticles and albucide, antimicrobial effects, reconstructive surgery in the orbit and periorbital area

Abstract

Background: It is important to develop orbital hydrogel implants capable of depositing drugs (particularly, antimicrobial and anticancer drugs).

Purpose: To assess antimicrobial effects of hybrid hydrogel implants containing gold nanoparticles and albucide and developed for reconstructive surgery in the orbit and periorbital area.

Material and Methods: A 30% aqueous solution of albucide was used in the study. Antimicrobial activity of synthesized hydrogels was determined using Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29213, Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 strains.

Results: All the synthesized samples of orbital hydrogel implants were sterile.

The synthesized hydrogels and hydrogel nanocomposites with incorporated Au nanoparticles demonstrated bacteriostatic effects against E. Coli ATCC 25922, E. Faecalis ATCC 29213, and S. Aureus ATCC 25923 strains, and bactericidal effects against P. Aeruginosa ATCC 27853 strain. This study also demonstrated marked bactericidal effects of hybrid hydrogel implants incorporating both Au nanoparticles and albucide.

Conclusion: Orbital hydrogel implants were found to be sterile after being sealed into polypropylene bags and steam sterilized at 121 °C for 20 minutes. Our findings of bacteriostatic and bactericidal effects of the synthesized hydrogels and hydrogel nanocomposites containing Au nanoparticles and albucide against bacterial strains of interest will allow for the absence of, or low probability of bacterial contamination in applications of these hydrogels in implants.

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Published

2023-11-01

How to Cite

1.
Samchenko YM, Dybkova SM, Maletskyi A, Kernosenko LO, Gruzina TG, Pasmurtseva NO, Rieznichenko LS, Liutko OB, Vitrak KV, Bigun NM, Vorotytskyi PV, Mamyshev II. Antimicrobial effects of hydrogel implants incorporating gold nanoparticles and albucide and developed for reconstructive surgery in the orbit and periorbital area. J.ophthalmol. (Ukraine) [Internet]. 2023 Nov. 1 [cited 2024 Nov. 6];(5):27-33. Available from: https://ua.ozhurnal.com/index.php/files/article/view/65

Issue

Section

Clinical Ophthalmology

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