Pathogenetic treatment for neurotrophic keratopathy

Authors

  • T. B. Gaidamaka SI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine"; Odesa (Ukraine)
  • T. A. Veliksar SI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine"; Odesa (Ukraine)
  • G. I. Drozhzhyna SI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine"; Odesa (Ukraine)
  • T. M. Serebrina SI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine"; Odesa (Ukraine)

DOI:

https://doi.org/10.31288/oftalmolzh/2018/2/710

Keywords:

neurotrophic keratopathy, contact lenses, thiotriazoline, electrophoresis

Abstract

Introduction. Continuous soft contact lens (SCL) wearing can result in development of neurotrophic keratopathy. Treatment of this pathology is long-term and, in general, symptomatic: tear-substitute, epithelizing, vitaminous, antibacterial, anti-inflammatory therapy. Purpose. To improve a correction method for metabolic alterations in corneal tissues in continuous-SCL-wear-associated neurotrophic keratopathy through using transorbital electrophoresis with 1% thiotriazoline.   Material and Methods. We developed a method of treatment for neurotrophic keratopathy which includes a 10 day course of daily transorbital electrophoresis with 1% thiotriazoline as a part of complex therapy. We applied for approval of Author's certificate (application No U 201710621 dated 01 November 2017). Results. Clinical cases of treatment of stage 1 neurotrophic keratopathy are reported.    Conclusion. The proposed treatment enables in a short term to significantly decrease pathological changes in corneal tissues in stage 1 neurotrophic keratopathy, to increase comfort in the eyes, to prevent severe complications of neurotrophic keratopathy and soft contact lens wearing. 

References

Drozhzhina GI, Ivanova ON, Gaidamaka TB. et al. Severe corneal infections induced by contact lens wearing. J.ophthalmol.(Ukraine).2016;6:38-42. https://doi.org/10.31288/oftalmolzh201663842

Cavanagh HD, Petroll M, Alizadeh H et al. Clinical and diagnostic use of in vivo confocal microscopy in patients with corneal disease. Ophthalmology. 1993;100(10):1444 - 53. https://doi.org/10.1016/S0161-6420(93)31457-0

Dart JK, Radford CF, Minassian D, Verma S, Stapleton F. Risk factors for microbial keratitis with contemporary contact lenses: a case-control study. Ophthalmology.2008;115(10):1647-54. https://doi.org/10.1016/j.ophtha.2008.05.003

Ziadi M, Moiroux P, d'Athis P et al. Assessment of induced corneal hypoxia in diabetic patients. 2002;21(5):453-7. https://doi.org/10.1097/00003226-200207000-00004

Gaidamaka T, Veliksar T, Drozhzhyna G, Hramenko N. [Condition of tear film, conjunctiva, limbus and cornea in long-term use of siliconehydrogel contact lenses]. Oftalmologiia. Vostochnaia Evropa. 7(3): 289-98. Russian.

Sacchetti M, Lambiase A. Diagnosis and management of neurotrophic keratitis. Clin. Ophthalmol. 2014;8:571−9. https://doi.org/10.2147/OPTH.S45921

Trofimova TS, Briuzgina TS, Chekman IS. [Effect of thiotriazolinum on lipid indices in the liver and the heart of rats in toxic action of doxorubicin]. Zaporozh. med. zhurn. 2005;1:124-6. Ukrainian.

Cherikchi LE. [Physiotherapy in ophthalmology]. Kyiv: Zdorovya;1979:3-4;53-4. Russian.

Chekman IS, Replianchuk ND. [Use of thiotriazolinum and corneregel in pharmacotherapy of dystrophic diseases of the anterior eye]. [Proceedings of scientific practical conference "Filatov Memorial Lectures - 2013": 52-3. Ukrainian.

Downloads

Published

2026-01-14

How to Cite

[1]
Gaidamaka, T.B. et al. 2026. Pathogenetic treatment for neurotrophic keratopathy. Ukrainian Journal of Ophthalmology . 2 (Jan. 2026), 7–10. DOI:https://doi.org/10.31288/oftalmolzh/2018/2/710.

Issue

No. 2 (2018): Journal of Ophthalmology (Ukraine)

Section

Clinical Ophthalmology

License

Copyright (c) 2025 Т. Б. Гайдамака, Т. А. Веліксар, Г. І. Дрожжина, Т. М. Серебрина

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.

COPYRIGHT NOTICE

Authors who publish in this journal agree to the following terms:

  1. Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
  2. The copyright commencement date complies the publication date of the issue, where the article is included in.

DEPOSIT POLICY

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
  3. Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
  4. Archiving the pre-print (pre-refereeing manuscript version) not allowed.

Most read articles by the same author(s)

1 2 > >> 

Similar Articles

1 2 > >> 

You may also start an advanced similarity search for this article.