A Comparative analysis of lens structural changes in ex-clean-up workers exposed to radiation from Chornobyl versus non-exposed individuals

E. Grisle; A. Zemitis; I. Markevica; M. Zolovs; G. Laganovska

doi:10.31288/oftalmolzh202445257

Authors

E. Grisle Pauls Stradins Clinical University hospital, Riga, Latvia https://orcid.org/0009-0004-0052-5437
A. Zemitis Riga Stradins University, Pauls Stradins Clinical University Hospital, Riga, Latvia
I. Markevica Riga Stradins University, Pauls Stradins Clinical University Hospital, Riga, Latvia
M. Zolovs Riga Stradins University, Riga (Latvia); Daugavpils University, Institute of Life Sciences and Technology, Daugavpils (Latvia)
G. Laganovska Riga Stradins University, Pauls Stradins Clinical University Hospital, Riga, Latvia

DOI:

https://doi.org/10.31288/oftalmolzh202445257

Keywords:

Ionising radiation, nuclear power plant, radiation accident, cataract

Abstract

Purpose. The purpose of this research was to measure lens posterior cortex thickness and compare it between Chornobyl ex-clean-up workers and healthy individuals to determine whether Chornobyl ex-clean-up workers have a higher prevalence of posterior cortex cataract.
Methods. The study was conducted on 32 eyes of healthy, non-exposed individuals, 32 eyes of individuals who worked only in Chornobyl City, and 16 eyes of individuals who worked on the roof of the reactor. All measurements were performed using a Heidelberg Anterion device. Statistical analyses were performed using Jamovi statistical software.
Results. The results showed that those who had worked on the roof of the reactor had a significantly higher percentage of their lens occupied by the posterior cortex (median 17.3%, IQR 15.5–18.5%) compared to both the controls and city workers. Therefore, they also have a higher prevalence of posterior subcapsular cataracts (p<0.001).
Conclusion. Exposure to increased radiation doses can cause alterations in various body structures, including the lens. Numerous studies have posited that heightened radiation exposure can induce substantial alterations in ocular structural integrity. Conversely, other studies have yielded results that exhibit higher degrees of uncertainty and ambiguity.

References

Dolin PJ. Ultraviolet radiation and cataract: a review of the epidemiological evidence. Br J Ophthalmol, 1994. 78(6): p. 478-82. https://doi.org/10.1136/bjo.78.6.478

Asbell PA, et al., Age-related cataract. Lancet. 2005; 365(9459): 599-609. https://doi.org/10.1016/S0140-6736(05)70803-5

Löfgren S. Solar ultraviolet radiation cataract. Exp Eye Res. 2017; 156: 112-116. https://doi.org/10.1016/j.exer.2016.05.026

Hightower KR. The role of the lens epithelium in development of UV cataract. Curr Eye Res, 1995. 14(1): p. 71-8. https://doi.org/10.3109/02713689508999916

Michael R. Development and repair of cataract induced by ultraviolet radiation. Ophthalmic Res. 2000; 32 Suppl 1: ii-iii; 1-44. https://doi.org/10.1159/000055633

Balasubramanian D. Ultraviolet radiation and cataract. J Ocul Pharmacol Ther. 2000; 16(3): 285-97. https://doi.org/10.1089/jop.2000.16.285

Bond VP, Fishler MC, Sullivan WH. The physician and the atomic bomb. Calif Med. 1951; 75(6): 400-7.

Rehani MM, et al. Radiation and cataract. Radiat Prot Dosimetry. 2011; 147(1-2): 300-4. https://doi.org/10.1093/rpd/ncr299

Strigari L, et al. Dose-Effects Models for Space Radiobiology: An Overview on Dose-Effect Relationships. Front Public Health. 2021; 9: 733337. https://doi.org/10.3389/fpubh.2021.733337

Shore RE, Neriishi K, Nakashima E. Epidemiological studies of cataract risk at low to moderate radiation doses: (not) seeing is believing. Radiat Res. 2010; 174(6): 889-94. https://doi.org/10.1667/RR1884.1

Oosta GM, Mathewson NS. Effect of high-power density microwave irradiation on the soluble proteins of the rabbit lens. Invest Ophthalmol Vis Sci. 1979; 18(4): 391-400.

Weir JR. Radiation damage, at high temperatures. Science. 1967; 156(3783): 1689-95. https://doi.org/10.1126/science.156.3783.1689

Stewart WG. Radiation hazards control in survival operations in the event of a nuclear war. Can Med Assoc J. 1962; 87(22): 1173-7.

Pickering JE, Vogel FS. Demyelinization induced in the brains of monkeys by means of fast neutrons; pathogenesis of the lesion and comparison with the lesions of multiple sclerosis and Schilder's disease. J Exp Med. 1956; 104(3): 435-42. https://doi.org/10.1084/jem.104.3.435

Waters WR. Reduction of fallout radiation hazards in health installations. Can Med Assoc J. 1962; 87(22): 1177-83.

Littlefield LG et al. Do recorded doses overestimate true doses received by Chernobyl cleanup workers? Results of cytogenetic analyses of Estonian workers by fluorescence in situ hybridization. Radiat Res. 1998; 150(2): 237-49. https://doi.org/10.2307/3579859

Monte L et al. Assessment of state-of-the-art models for predicting the remobilisation of radionuclides following the flooding of heavily contaminated areas: the case of Pripyat River floodplain. J Environ Radioact. 2006; 88(3): 267-88. https://doi.org/10.1016/j.jenvrad.2006.02.006

Levin SG, Young RW, Stohler RL. Estimation of median human lethal radiation dose computed from data on occupants of reinforced concrete structures in Nagasaki, Japan. Health Phys. 1992; 63(5): 522-31. https://doi.org/10.1097/00004032-199211000-00003

Park MY, Jung SE. Patient Dose Management: Focus on Practical Actions. J Korean Med Sci. 2016; 31 Suppl 1(Suppl 1): S45-54. https://doi.org/10.3346/jkms.2016.31.S1.S45

Roberts WC. Facts and ideas from anywhere. Proc (Bayl Univ Med Cent). 2018; 31(2): 257-267. https://doi.org/10.1080/08998280.2018.1441481

Laćan I, McBride J, Witt D. Urban forest condition and succession in the abandoned city of Pripyat, near Chernobyl, Ukraine. Urban Forestry & Urban Greening, 2015. 14. https://doi.org/10.1016/j.ufug.2015.09.009

Likhtarev IA, Chumack VV, Repin VS. Retrospective reconstruction of individual and collective external gamma doses of population evacuated after the Chernobyl accident. Health Phys. 1994; 66(6): 643-52. https://doi.org/10.1097/00004032-199406000-00004

Drozdovitch V. Radiation Exposure to the Thyroid After the Chernobyl Accident. Front Endocrinol (Lausanne). 2020; 11: 569041. https://doi.org/10.3389/fendo.2020.569041

Havlik E, Bergmann H, Höfer R. [Diagnosis of radionuclide uptake using a whole body counter]. Acta Med Austriaca. 1986; 13(4-5): 99-101.

Baverstock KF. A preliminary assessment of the consequences for inhabitants of the UK of the Chernobyl accident. Int J Radiat Biol Relat Stud Phys Chem Med. 1986; 50(1): iii-xiii. https://doi.org/10.1080/09553008614550381

Marino F, Nunziata L. Long-Term Consequences of the Chernobyl Radioactive Fallout: An Exploration of the Aggregate Data. Milbank Q. 2018; 96(4): 814-857. https://doi.org/10.1111/1468-0009.12358

Loganovsky KN et al. Radiation-Induced Cerebro-Ophthalmic Effects in Humans. Life (Basel). 2020. 10(4). https://doi.org/10.3390/life10040041

Pasyechnikova N, Fedirko P, Babenko T. A case of radiation cataract found 29 years after radiation exposure. Oftalmologicheskii Zhurnal. 2020; 89: 61-63. https://doi.org/10.31288/oftalmolzh202066163

Charles MW, Brown N. Dimensions of the human eye relevant to radiation protection. Phys Med Biol. 1975; 20(2): 202-18. https://doi.org/10.1088/0031-9155/20/2/002

Ainsbury EA et al. Radiation cataractogenesis: a review of recent studies. Radiat Res. 2009; 172(1): 1-9. https://doi.org/10.1667/RR1688.1

Lipman RM, Tripathi BJ, Tripathi RC. Cataracts induced by microwave and ionizing radiation. Surv Ophthalmol. 1988; 33(3): 200-10. https://doi.org/10.1016/0039-6257(88)90088-4

Worgul BV et al. Lens epithelium and radiation cataract. I. Preliminary studies. Arch Ophthalmol. 1976; 94(6): 996-9. https://doi.org/10.1001/archopht.1976.03910030506013

Worgul BV et al. UACOS - the Ukrainian/American Chernobyl ocular study. in International conference on radiation and health Program and book of abstracts. 1996. Israel.

Lerebours A et al. Evaluation of cataract formation in fish exposed to environmental radiation at Chernobyl and Fukushima. Sci Total Environ. 2023; 902: 165957. https://doi.org/10.1016/j.scitotenv.2023.165957

Darte JM, Little WM Management of the acute radiation syndrome. Can Med Assoc J. 1967; 96(4): 196-9.