Імунний статус хворих с фронто-базальною травмою при використанні імпланта «Синтекість» при хірургічному лікуванні

О.D. Bondarchuk; V.V. Kishchuk; О.F. Melnykov; М.D. Tymchenko; N.D. Didyk

doi:10.31288/oftalmolzh201943842

Authors

О.D. Bondarchuk Mykola Pyrohov Vinnytsia National Medical University; Vinnytsia (Ukraine), Mykola Pyrohov Vinnytsia Regional Hospital; Vinnytsia (Ukraine)
V.V. Kishchuk Mykola Pyrohov Vinnytsia National Medical University; Vinnytsia (Ukraine)
О.F. Melnykov Prof. O.S. Kolomiychenko Otolaryngology Institute of NAMS; Kyiv (Ukraine)
М.D. Tymchenko Prof. O.S. Kolomiychenko Otolaryngology Institute of NAMS; Kyiv (Ukraine)
N.D. Didyk Mykola Pyrohov Vinnytsia Regional Hospital; Vinnytsia (Ukraine)

DOI:

https://doi.org/10.31288/oftalmolzh201943842

Keywords:

trauma to the frontal bone, immunoglobulins, interleukins, biocomposite SYNTEKIST

Abstract

Aim. To determine the influence of a biocomposite on the state of the immune system of patients with trauma to the frontal bone at 1 month after surgical treatment.

Materials and Methods. 20 patients with frontal bone fracture treated surgically with and without a SYNEKIST biocomposite were examined; 10 patients served as control. Immunoglobulins M, G, A, and E were determined in the blood serum using enzyme-linked immunosorbent assay. We also determined the content of prodefensin (lactoferrin, an indicator of the acute phase of inflammation), interleukins IL-1?, and interleukin-10.

Results. On presentation and during the first days, the patients with trauma to the frontal bone had a decreased level of IgM which, however, reached the control level and was practically the same in both groups. There were no changes in other immunoglobulins in a month. The level of pro-inflammatory Il-a was increased on admission with a significant decrease within the first month in both treatment approaches. The on-admission level of pro-inflammatory cytokines did not differ significantly from the control while its level increased in the patients undergone the surgical treatment using a biocomposite material. The level of lactoferrin decreased to normal ranges in both treatment approaches.

Conclusions. The advantage of the surgical treatment using a biocomposite material lies in the restoration of the IgM level and activation of anti-inflammatory mechanisms, Il-10, in particular, in 1 month.

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