SD OCT retinal thickness in the macula area in premature children who received laser photocoagulation of avascular retina for severe ROP
DOI:
https://doi.org/10.31288/oftalmolzh201912932Keywords:
retinopathy of prematurity, retinal thickness, SD OCT, smooth foveal depressionAbstract
Background: Immature ocular optics at birth and severe retinopathy of prematurity (ROP) may affect normal development of the retina and lead to late impairment of visual functions.
Purpose: To compare spectral-domain optical coherence tomography (SD OCT) retinal thickness in the macular area between premature children who received laser photocoagulation of avascular retina (LPCAR) and full-term children aged 4-6 years.
Materials and Methods: Twenty-five premature children (50 eyes) and 38 full-term control children (69 eyes without eye disease) aged 4-6 years received observation care at the Filatov institute between 2011 and 2017. The inclusion criterion for premature children was receiving LPCAR for severe (type 1 subthreshold, or threshold) ROP diagnosed during screening. Patients with grade 4 or 5 ROP or other ocular pathology (history of cataract, glaucoma, trauma or eye surgery) were excluded.
Results: There was a significant difference in retinal thickness in the macular area between premature and full-term children; the magnitude of the difference depended on the severity of ROP. The foveal-to-central thickness ratio was found to be increased compared to controls by at least 0.1 in 18 premature children (36 eyes, 72%) who received LPCAR (p <0.05).
Conclusion: Mean SD OCT retinal thicknesses in all macular sectors in premature children who received LPCAR for ROP were greater than in full-term children.
References
1.Larsson E, Rydberg A, Holmstrom G. Contrast sensitivity in 10 year old preterm and full term children: a population based study. Br J Ophthalmol. 2006 Jan; 90(1): 87-90. https://doi.org/10.1136/bjo.2005.081653
2.Wang J, Spencer R, Leffler JN, Birch EE. Critical period for foveal fine structure in children with regressed retinopathy of prematurity. Retina. 2012 Feb;32(2):330-9.https://doi.org/10.1097/IAE.0b013e318219e685
3.Eriksson U, Holmström G, Alm A, Larsson E. A population-based study of macular thickness in full-term children assessed with Stratus OCT: normative data and repeatability. Acta Ophthalmol. 2009 Nov;87(7):741-5.https://doi.org/10.1111/j.1755-3768.2008.01357.x
4.Akerblom H, Larsson E, Eriksson U, Holmstrom G. Central macular thickness is correlated with gestational age at birth in prematurely born children. Br J Ophthalmol. 2011 Jun;95(6):799-803.https://doi.org/10.1136/bjo.2010.184747
5.Pasyechnikova NV, Naumenko VA, Zborovska OV. [Foveal to central thickness ratio as an early sign of retinal macular edema]. Oftalmol Zh. 2004;5:4-6. Russian.
6.Ecsedy M, Szamosi A, Karkó C, et al. A comparison of macular structure imaged by optical coherence tomography in preterm and full-term children. Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5207-11.https://doi.org/10.1167/iovs.06-1199
7.Chen YH, Lien R, Chiang MF, et al. Outer Retinal Structural Alternation and Segmentation Errors in Optical Coherence Tomography Imaging in Patients With a History of Retinopathy of Prematurity. Am J Ophthalmol. 2016 Jun;166:169-180.https://doi.org/10.1016/j.ajo.2016.03.030
8.Samarawickrama C, Wang JJ, Huynh SC, et al. Macular thickness, retinal thickness, and optic disk parameters in dominant compared with nondominant eyes. AAPOS. 2009 Apr;13(2):142-7.https://doi.org/10.1016/j.jaapos.2008.11.004
9.El-Dairi MA, Asrani SG, Enyedi LB, Freedman SF. Optical coherence tomography in the eyes of normal children. Arch Ophthalmol. 2009 Jan;127(1):50-8.https://doi.org/10.1001/archophthalmol.2008.553
10.Stoica F, Chirita-Ermandi A, Andreescu N, Stanciu A, Zimbru CG, Puiu M. Clinical relevance of retinal structure in children with laser-treated retinopathy of prematurity versus controls - using optical coherence tomography. Acta Ophthalmol. 2018 Mar;96(2):e222-e228. Epub 2017 Sep 19.https://doi.org/10.1111/aos.13536
11.Yanni SE, Wang J, Chan M, et al. Foveal avascular zone and foveal pit formation after preterm birth. Br J Ophthalmol. 2012 Jul;96(7):961-6.https://doi.org/10.1136/bjophthalmol-2012-301612
12.Yuodelis C, Hendrickson A. A qualitative and quantitative analysis of the human fovea during development. Vision Res. 1986;26(6):847-55.https://doi.org/10.1016/0042-6989(86)90143-4
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