Serum TNF-α and IL-1β levels in patients with RNFL thinning in uveitis complicated by optic nerve inflammation
DOI:
https://doi.org/10.31288/oftalmolzh202061418Keywords:
uveitis, complicated by optic nerve inflammation, TNF-α, IL-1βAbstract
Purpose: To assess serum tumor necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β) levels in patients with retinal nerve fiber layer (RNFL) thinning in uveitis complicated by optic nerve inflammation.
Material and Methods: One hundred and thirty-two patients underwent examination and treatment. Serum TNF-α and IL-1β levels were determined by commercially available enzyme-linked immunoassay kits.
Results: The serum TNF-α level was more than 1.5 times higher in patients with uveitis complicated by optic nerve inflammation who had reduced RNFL thickness compared to patients with normal RNFL thickness (p < 0.05), and the serum IL-1β level was 17% higher in the former patients than in the latter patients (p > 0.05).
Conclusion: In the active stage of uveitis, the serum TNF-α level was significantly higher in patients with RNFL thinning due to uveitis complicated by optic nerve inflammation compared to patients with normal RNFL thickness, and the serum IL-1β level was higher in the former patients than in the latter patients, but the difference was not statistically significant. The results of the study may justify the use of biologic therapy in the treatment of uveitis complicated by optic nerve inflammation.
References
1.Abu El-Asrar AM, Struyf S, Kangave D, Al-Obeidan SA, Opdenakker G, Geboes K, Van Damme J. Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis. Cytokine. 2012;59(2):377-81.https://doi.org/10.1016/j.cyto.2012.04.030
2.Chen W, Zhao B, Jiang R, Zhang R, Wang Y, Wu H, Gordon L, Chen L. Cytokine expression profile in aqueous humor and sera of patients with acute anterior uveitis. Curr Mol Med. 2015;15(6):543-9.https://doi.org/10.2174/1566524015666150731100012
3.Hernández Garfella ML, Palomares Fort P, Román Ivorra J, Cervera Taulet E. Aqueous Humor Levels of Different Interleukins 1-β, 2, 6 and 10, Tumor Necrosis Factor-α and Vascular Endothelial Growth Factor in Uveitis Treated with Adalimumab. J Ophthalmic Vis Res. 2015 Jan-Mar;10(1):49-54.https://doi.org/10.4103/2008-322X.156110
4.Zhao B, Chen W, Jiang R, Zhang R, Wang Y, Wang L, Gordon L, Chen L. Expression profile of IL-1 family cytokines in aqueous humor and sera of patients with HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. Exp Eye Res. 2015;138:80-86.https://doi.org/10.1016/j.exer.2015.06.018
5.Nagata K, Maruyama K, Uno K, Shinomiya K, Yoneda K, Hamuro J, Sugita S, Yoshimura T, Sonoda KH, Mochizuki M, Kinoshita S. Simultaneous analysis of multiple cytokines in the vitreous of patients with sarcoid uveitis. Invest Ophtalmol Vis Sci. 2012;53(7):3827-33.https://doi.org/10.1167/iovs.11-9244
6.Shibata M, Sato T, Taguchi M, Tanaka A, Harimoto K, Takeuchi M. Analysis of Cytokines Related to Helper T and Regulatory T Cells in the Vitreous of Uveitis Patients. Nippon Ganka Gakkai Zasshi. 2015 Jun;119(6):395-401.
7.Chekaoui A, Lahmar K, Belguendouz H, Mazari F, Terahi M, Hakem D, Youinou P, Touil-Boukoffa C. Increased IL-1β levels are associated with an imbalance of "oxidant/antioxidant" status during Behçet's disease. Eur Cytokine Netw. 2018;29(3):95-102.https://doi.org/10.1684/ecn.2018.0411
8.Cordero-Coma M, Calleja S, Llorente Rodriguez E, Franco M, Ruiz de Morales JG. Serum cytokine profile in adalimumab-treated refractory uveitis patients: decreased IL-22 correlates with clinical responses. Ocul Immunol Inflamm. 2013 Jun; 21(3):212-9.https://doi.org/10.3109/09273948.2013.770888
9.Gholijani N, Ataollahi MR, Samiei A, Aflaki E, Shenavandeh S, Kamali-Sarvestani E. An elevated pro-inflammatory cytokines profile in Behcet's disease: A multiplex analysis. Immunol Lett. 2017;186:46-51.https://doi.org/10.1016/j.imlet.2016.12.001
10.Mesquida М. Molins B, Llorens V, Sainz de la Maza M, Hernandez MV, Espinosa G, Adán A. Proinflammatory cytokines and C-reactive protein in uveitis associated with Behcet's disease. Mediators Inflamm [Internet]. 2014 Jun 8.https://doi.org/10.1155/2014/396204
11.Türkcü FM, Şahin A, Cingü AK, Kaya S, Yuksel H, Cinar Y, Batmaz I. Serum omentin, resistin and tumour necrosis factor-α levels in Behcet patients with and without ocular involvement. Graefes Arch Clin Exp Ophthalmol. 2015;253(9):1565-68.https://doi.org/10.1007/s00417-015-3016-0
12.Zhao R, Zhou H, Zhang J, Liu X, Su SB. Interleukin-1β promotes the induction of retinal autoimmune disease. Int Immunopharmacol. 2014;22(2):285-92.https://doi.org/10.1016/j.intimp.2014.06.041
13.Tseng WA, Thein T, Kinnunen K, Lashkari K, Gregory MS, D'Amore PA, Ksander BR. NLRP3 Inflammasome Activation in Retinal Pigment Epithelial Cells by Lysosomal Destabilization: Implications for Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2013;54(1):110-20.https://doi.org/10.1167/iovs.12-10655
14.Mac Nair CE, Fernandes KA, Schlamp CL, Libby RT, Nickells RW. Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush. J Neuroinflammation. 2014;11:194.https://doi.org/10.1186/s12974-014-0194-3
15.Kozak de Y, Naud MC, Bellot J, Faure JP, Hicks D. Differential Tumor Necrosis Factor Expression by Resident Retinal Cells From Experimental Uveitis-Susceptible and -Resistant Rat Strains. J Neuroimmunol. 1994 Nov;55(1):1-9.https://doi.org/10.1016/0165-5728(94)90141-4
16.Kitaoka Y, Sase K, Tsukahara C, Kojima K, Shiono A, Kogo J, Tokuda N, Takagi H. Axonal protection by ripasudil, a Rho kinase inhibitor, via modulating autophagy in TNF-Induced optic nerve degeneration. Invest Ophthalmol Vis Sci. 2017;58:5056-64. https://doi.org/10.1167/iovs.17-22000
17.Madigan MC, Sadun AA, Rao NS, Dugel PU, Tenhula WN, Gill PS. Tumor necrosis factor-alpha (TNF-alpha)-induced optic neuropathy in rabbits. Neurol Res. 1996;18(2):176-84.https://doi.org/10.1080/01616412.1996.11740399
18.Tsukahara C, Sase K, Fujita N, Takagi H, Kitaoka Y. Axonal Protection by Tacrolimus with Inhibition of NFATc1 in TNF-Induced Optic Nerve Degeneration. Neurochem Res. 2019;44(7):1726-35.https://doi.org/10.1007/s11064-019-02804-6
19.Paschalis EI, Zhou C, Lei F, Scott N, Kapoulea V, Robert MC, Vavvas D, Dana R, Chodosh J, Dohlman CH. Mechanisms of Retinal Damage after Ocular Alkali Burns. Am J Pathol. 2017;187(6):1327-42.https://doi.org/10.1016/j.ajpath.2017.02.005
20.Panchenko NV, Samofalova MN, Gonchar EN, Prikhodko DO, Arustamova GS, Litvishenko AV. [Alterations in the expression of tumor necrosis factor-alpha in the uveitis with optic nerve inflammation]. Oftalmol Zh. 2016;5:18-21. Russian.
21.Evereklioglu C, Er H, Turkoz Y, Cekmen M. Evereklioglu C. Serum levels of TNF-alpha, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behçet's disease. Mediators Inflamm. 2002 Apr;11(2):87-93.https://doi.org/10.1080/09629350220131935
22.Santos Lacomba M, Marcos Martín C, Gallardo Galera GM, Gómez Vidal MA, Collantes Estévez E, Ramírez Chamond R, Omar M. Aqueous humor and serum tumor necrosis factor-alpha in clinical uveitis. Ophthalmic Res. Sep-Oct 2001;33(5):251-5.https://doi.org/10.1159/000055677
23.Takase H, Futagami Y, Yoshida T, Kamoi K, Sugita S, Imai Y, Mochizuki M. Cytokine Profile in Aqueous Humor and Sera of Patients with Infectious or Noninfectious Uveitis. Invest Ophtalmol Vis Sci. 2006;47(4):1557-61.https://doi.org/10.1167/iovs.05-0836
24.Katome T, Namekata K, Guo X, Semba K, Kittaka D, Kawamura K, Kimura A, Harada C, Ichijo H, Mitamura Y, Harada T. Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury. Cell Death Differ. 2013;20(2):270-80.https://doi.org/10.1038/cdd.2012.122
25.Bariş S, Akyürek Ö, Dursun A, Akyol M. The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype. Med Clin (Barc). 2016;146(9):379-83.https://doi.org/10.1016/j.medcli.2015.09.017
26.Kitaoka Y, Tanito M, Kojima K, Sase K, Kaidzu S, Munemasa Y, Takagi H, Ohira A, Yodoi J. Axonal protection by thioredoxin-1 with inhibition of interleukin-1β in TNF-induced optic nerve degeneration. Exp Eye Res. 2016;152:71-76.https://doi.org/10.1016/j.exer.2016.09.007
27.Sivakumar V, Foulds WS, Luu CD, Ling EA, Kaur C. Retinal Ganglion Cell Death Is Induced by Microglia Derived Pro-Inflammatory Cytokines in the Hypoxic Neonatal Retina. J Pathol. 2011;224(2):245-60.https://doi.org/10.1002/path.2858
28.Panchenko NV, Samofalova MN, Friantseva MV. [Concentration of matrix metalloproteinase-9 at different outcome of uveitis complicated by inflammation of the optic optic nerve]. Oftalmologiia. Vostochnaia Evropa. 2016;6(2):210-6. Russian.
29.Yamada H, Yoneda M, Inaguma S, Watanabe D, Banno S, Yoshikawa K, Mizutani K, Iwaki M, Zako M. Infliximab counteracts tumor necrosis factor-α-enhanced induction of matrix metalloproteinases that degrade claudin and occludin in non-pigmented ciliary epithelium. Biochem Pharmacol. 2013 Jun;85(12):1770-82.https://doi.org/10.1016/j.bcp.2013.04.006
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