Optimizing the management of dry eye in corneal and conjunctival cicatrization secondary to severe burns to the eye
DOI:
https://doi.org/10.31288/oftalmolzh202123639Keywords:
burns to the eye, dry eye disease, tear productionAbstract
Background: Investigation of the pathogenesis of dry eye disease (DED) in corneal and conjunctival cicatrization secondary to severe burns to the eye as well as optimization of the management of this condition is an important and relevant task of clinical ophthalmology.
Purpose: To optimize the management of DED in corneal and conjunctival cicatrization secondary to severe burns to the eye on the basis of tear production studies.
Material and Methods: Forty patients (60 eyes) with DED and corneal and conjunctival cicatrization secondary to severe burns to the eye and showing various reductions in Schirmer test 1 scores were included in the study. Tear substitutes (Tear Naturale; Alcon, Fort Worth, TX) or Vidisic® gel (Mann Pharma, Berlin, Germany) were administered four times a day for eyes with mild or moderate dry eye, and six times a day for eyes with severe dry eye, and tear production was assessed at 2 weeks and at 3 months.
Results: At two weeks, among the eyes treated with Vidisic gel, Schirmer test score improved from 12 mm to 13 mm (p > 0.05) for eyes with mild dry eye, from 6.5 mm to 8.4 mm for eyes with moderate dry eye, and from 3.1 mm to 6.3 mm for eyes with severe dry eye. In addition, among the eyes treated with teas substitutes, Schirmer test score improved from 11 mm to 13 mm for eyes with mild dry eye, from 6.1 mm to 8.1 mm for eyes with moderate dry eye, and from 2.6 mm to 4.4 mm for eyes with severe dry eye (p < 0.05). At three months, patients who were taking their medication as per schedule had approximately the same scores as at two weeks, whereas those who discontinued taking their medication or were taking it irregularly had approximately the same scores as at baseline.
Conclusion: Our findings highlight the necessity of continuous tear substitute treatment for patients with DED and corneal and conjunctival cicatrization secondary to severe burns to the eye.
References
1.Brzheskii VV, Somov EE. [Dry eye syndrome]. St. Petersburg: Apollon; 1998. Russian.
2.Brzheskii VV, Somov EE. [Dry eye syndrome]. 2nd ed., revised and expanded. St. Petersburg: Levsha; 2003. Russian.
3.Brzheskii VV. [Tactics of medicamental treatment of patients with various clinical forms of dry eye syndrome]. Klinicheskaia oftalmologiia. 2008;9(1):4-6. Russian.
4.Drozhzhyna GI. [Inflammatory disorders of eyelids]. Odesa: Astroprint; 2011. Russian.
5.Drozhzhyna GI. [Current methods of treatment for dry eye disease]. Oftalmol Zh. 2013;5:3-9. Russian.
6.Zhaboiedov GD, Kireiev VV. [Dry eye syndrome: current state of the problem]. Oftalmol Zh. 2005;5:4-14. Ukrainian.
7.Iakimenko SA, Amjad Albin. [Tear production in patients with corneal and conjunctival cicatrization secondary to severe burns to the eye]. Oftalmol Zh. 2015;1:5-9. Russian.
8.Iakimenko SA, Amjad Albin. [Tear production in conjunctival and corneal xerosis and opportunities for its treatment]. Oftalmol Zh. 2015;2:16-21. Russian.
9.Iakimenko SA, Amjad Albin, Kolomiichuk SG. [Determination of the level of the protective components in the tear fluid in patients with scarring consequences of the eye burns]. Oftalmol Zh. 2014;3:19-24. Russian.
10.Iakimenko SA, Amzhad Albin, Parkhomenko TV. [Study of lipid peroxidation products in tear fluid of patients with corneal and conjunctival cicatrization secondary to burns to the eye]. Oftalmol Zh. 2014;4:14-9. Russian.
11.Iakimenko SA, Amjad Albin, Kolomiichuk SG. [Investigating the antioxidative potential of tear fluid in patients with cicatrization secondary to burns to the eye complicated by dry eye disease and opportunities for correcting this condition]. Oftalmologiia. Vostochnaia Evropa. 2014;3:19-24. Russian.
12.Iakimenko SA, Artiomov AV, Amjad Albin. [Morphological characteristics of the conjunctiva and labial mucosa in patients with cicatrization secondary to burns to the eye after reconstructive and plastic surgeries]. Oftalmologiia. Vostochnaia Evropa. 2015;1(24):30-7. Russian.
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