Antioxidant system by the consentration levels of the free and connected albuminous sulphidic and disulphidic groups in a tear liquid depending on degree of myopia in children
DOI:
https://doi.org/10.31288/oftalmolzh201514144Keywords:
Myopia in children, antioxidant systemAbstract
Material and methods. There were 34(68 eyes) children at the age of 8–14 under observation. Among them there were children with myopia of mild degree (7), moderate degree (10), and high degree (7) as well as a control group healthy of children of the same age — 10 people. Visometry, ophthalmometry, refractometry in conditions of cycloplegia biomicroscopy and ophthalmocopy were made in all patients. Free and connected SH and S-S — groups in the tear fluid were determined by spectrocolormeter Spekol-210 with a wave length of 356 nm and 412 nm accordingly.
Results. It was established that in average values of connected SH and S-S — groups’ levels in the tear fluid had no significant difference in comparison with values in healthy children but it was found that SS — free and connected groups had the tendency to increase in average by (4.8–14.5) % depending on the myopic degree. Free SH- groups content in tear of children with high myopia was lower in comparison with the control group by 28 % (54. 2 ± 5.5) units, p<0.05.
Conclusions
1. Studies of SH- content in the tear fluid have shown that the level of antioxidant protection in myopia depends on its degree: the higher degree, the lower is the concentration of free SH-groups, and the lower level of antioxidant protection.
2. The tendency is noticed of the free and connected S-S-groups levels increase in the tear by (4.8 -14.5) % with degree of myopia that is evidence of the decrease of detoxic protection in these patients.
3. Significant decrease in the concentration of the SH — groups (by 28 %) in the tear fluid in children with myopia of high degree in comparison with healthy children speaks about disorder of the protective antioxidant system.
References
1.Boichuk IM, Surovaia EI. Antioxidant system in myopia. Problems, achievements and perspectives in the development of medical and biological science and practical health care. Papers of the Crimean State Medical University n/a S. I. Georgievskii. 2010. 34-36.
2.Lapkina II. The effectiveness of the modified treatment of patients with complicated myopia. Thesis for Candidate of Med. Science. Odessa. 2007. 22-23.
3.Petrovich YuA, Terekhina NA. Biochemistry of the tear and its change in pathology. Voprosy med. khimii. 1990;3:13-9. In Russian.
4.Terekhina NA, Petrovich YuA. Enzymatic analysis of tears in viral keratitis. Klinich. Lab. Diagnostika. 1994;6:15-7. In Russian.
5.Cohen SM, Olin KL, Feuer WJ et al. Low glutathione reductase and peroxidase activity in age - related macular degeneration. Br J Ophthalmol Oct. 1994;78(10):791-4. https://doi.org/10.1136/bjo.78.10.791
6.Gosbell AD, Stefanovic N, Scurr LL et al. Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1. Invest Ophthalmol Vis Sci. 2006; Jun 47(6):2613-22.https://doi.org/10.1167/iovs.05-0962
7.Jampol LM. Antioxidants and zinc to prevent progression of age-related macular degeneration.JAMA. 2001 Nov 2;286(19):2466-8.https://doi.org/10.1001/jama.286.19.2466
8.Samiec PS, Drews-Botsch C, Flagg EW et al. Glutathione in human plasma: decline in association with aging, age- related macular degeneration, and diabetes. Free Radic Biol Med. 1998 Mar 15;24(5):699-704.https://doi.org/10.1016/S0891-5849(97)00286-4
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 И. М. Бойчук, Е. И. Суровая, С. Г. Коломийчук
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.
