Comparing bioelectrical activity of the central retina among myopic patients operated for rhegmatogenous retinal detachment complicated by choroidal detachment
DOI:
https://doi.org/10.31288/oftalmolzh201841725Keywords:
rhegmatogenous retinal detachment, choroidal detachment, electroretinographyAbstract
Background: Rhegmatogenous retinal detachment (RRD) is a serious incapacitating disease requiring surgical treatment. Trophic disturbances in the central and peripheral retina are characteristic for myopia, which is known to be a major risk factor for RRD.
Purpose: 1) To investigate the bioelectrical activity of the central retina after successful surgery for combined RRD and CD in patients differing in the degree of myopia, and 2) to compare the characteristics with those of normal eyes and myopic patients successfully operated for uncomplicated RRD.
Materials and Methods: Fifty two patients (52 eyes) were included into the study 3 months after undergoing a single successful vitrectomy with gas tamponade, either for uncomplicated RRD (32 eyes), or combined RRD and CD (20 eyes). They were divided into four groups: Groups 1 and 2 (moderate and high myopes after surgery for uncomplicated RRD; 21 and 11 patients, respectively), and Groups 3 and 4 (moderate and high myopes after surgery for combined RRD and CD; 9 and 11 patients, respectively). Fourteen age-matched individuals (28 eyes) without any ocular or systemic disease were enrolled as controls (Group 5). Photopic cone response and photopic 30 Hz flicker cone response were recorded to examine the bioelectrical activity of the central retina.
Results: A-wave and b-wave implicit times of the photopic cone response (a) reflect conductance related to the photoreceptor and inner layers, respectively, of the central retina, and (b) were 25% longer and 28% longer, respectively, for myopic eyes after surgery for either uncomplicated RRD or combined RRD and CD, than for normal eyes. A-wave amplitude of the photopic cone response (a) reflects the summed bioelectrical activity of retinal photoreceptor cones, and (b) in moderately or highly myopic eyes after surgery for uncomplicated RRD was 1.9-fold and 3.5-fold lower, respectively, and in moderately or highly myopic eyes after surgery for combined RRD and CD, 3.9-fold and 6.6-fold lower, respectively, than in normal eyes. B-wave amplitude of the photopic cone response (a) reflects the summed bioelectrical activity of the retinal inner layers, and (b) in moderately or highly myopic eyes after surgery for uncomplicated RRD was 1.6-fold and 2.8-fold lower, respectively, whereas in those after surgery for combined RRD and CD, 3.8-fold lower, than in normal eyes. Amplitude of photopic 30 Hz flicker cone response (a) reflects the bioelectrical activity of cones, and (b) in moderately myopic eyes after surgery for uncomplicated RRD was 1.6-fold lower, whereas in myopic eyes after surgery for combined RRD and CD, 2.8-fold lower, than in normal eyes. We found direct correlations between BCVA and b-wave and a-wave amplitudes of the photopic cone response (r = 0.61 and r = 0.54, respectively), and amplitude of the 30 Hz flicker response (r = 0.53), and an inverse correlation (r=-0.53) between BCVA and a-wave implicit time of the photopic cone response for myopic eyes after surgery for either uncomplicated RRD or combined RRD and CD.
Conclusion: Bioelectrical activity of the central retina was found to be more decreased in highly myopic eyes after surgery for combined RRD and CD than in other myopic eyes of the study.
References
Jarrett WH. Rhegmatogenous retinal detachment complicated by severe intraocular inflammation, hypotony, and choroidal detachment. Trans Am Ophthalmol Soc. 1981;79:664-83
de Smedt S., Sullivan P. Massive choroidal detachment masking overlying primary rhegmatogenous retinal detachment: a case series. Bull Soc Belge Ophtalmol. 2001;(282):51-5.
Alibet Y, Levytska G, Umanets N, Pasyechnikova NV, Henrich B. Ciliary body thickness changes after preoperative anti-inflammatory treatment in rhegmatogenous retinal detachment complicated by choroidal detachment. Graefes Arch Clin Exp Ophthalmol. 2017 Aug;255(8):1503-8 https://doi.org/10.1007/s00417-017-3673-2
Alibet Y, Zadorozhnyy OS, Levytska GV, Pasyechnikova NV. [Visualization of ciliary body structures after preoperative anti-inflammatory treatment in rhegmatogenous retinal detachment complicated by choroidal detachment]. Journal of Ophthalmology. 2018; 1(480):54-9. Russian
Mitry D, Charteris DG, Yorson D, et al.; Scottish RD Study Group: The epidemiology and socioeconomic associations of retinal detachment in Scotland: a two-year prospective population-based study. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4963-8.https://doi.org/10.1167/iovs.10-5400
Park JL, Kim SD, Yun IH. A clinical study of the rhegmatogenous retinal detachment. Korean J Ophthalmol. 2002 Dec;15(2):118-27 https://doi.org/10.3341/kjo.2001.15.2.118
Park HJ, Lee SW, Kim KH, Lee JH, Lee JE, Oum BS. An Analysis of Metamorphopsia Using Preferential Hyperacuity Perimeter Following Macular-off RRD Surgical Repair. J Korean Ophthalmol Soc. 2010; 51(4):552-7. https://doi.org/10.3341/jkos.2010.51.4.552
Fisher SK, Lewis GP, Linberg KA, Verardo MR. Cellular remodeling in mammalian retina: results from studies of experimental retinal detachment. Prog Retin Eye Res. 24:395-431. https://doi.org/10.1016/j.preteyeres.2004.10.004
Sakai T, Tsuneoka H, Lewis GP, Fisher SK. Remodelling of retinal on- and off-bipolar cells following experimental retinal detachment. Clin Experiment Ophthalmol. 42:480-5. https://doi.org/10.1111/ceo.12246
Electroretinographic studies in rhegmatogenous retinal detachment before and after reattachment surgery. Korean J Ophthalmol. 2001 Dec;15(2):118-27 https://doi.org/10.3341/kjo.2001.15.2.118
Barliya T, Ofri R, Sandalon S, Weinberger D, Livnat T. Changes in Ret-inal Function and Cellular Remodeling Following Experimental Retinal Detachment in a Rabbit Model.. J Ophthalmol. 2017;2017:4046597. https://doi.org/10.1155/2017/4046597
Safety and efficacy of intravitreal injection of recombinant erythropoietin for protection of photoreceptor cells in a rat model of retinal detachment. Eye (Lond). 2012 Jan; 26(1): 144-52. https://doi.org/10.1038/eye.2011.254
Alibet Y, Ponomarchuk VS, Levytska GV, Khramenko NI. [Comparing bioelectrical activity of the peripheral retina among myopic patients operated for rhegmatogenous retinal detachment complicated by choroidal detachment]. Journal of Ophthalmology. 2018; 3:45-51. Russian
Atlas of testing and clinical application for Roland Electrophysiological Instrument. Beijing Science and Technology Press. 2006. pp.5-19.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Алибет Яссин, В. С. Пономарчук, Н. И. Храменко, Г. В. Левицкая
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.
