Comparative analysis of the impact of selected anesthesia methods on the cognitive function of patients undergoing ophthalmic surgery

Authors

  • V.M. Sakovych Dnipro State Medical University
  • G.S. Dorofeeva Dnipropetrovsk Regional Clinical Eye Hospital
  • V.P. Aleksieiev Dnipropetrovsk Regional Clinical Eye Hospital
  • O.V. Aleksieieva Dnipro State Medical University https://orcid.org/0000-0002-3106-4539
  • I.A. Drapak Dnipropetrovsk Regional Clinical Eye Hospital

DOI:

https://doi.org/10.31288/oftalmolzh202322125

Keywords:

pentylenetetrazol kindling, chronic epileptic syndrome, retinopathy, niacin-oxy-ethylidene-phosphonate germinate (MIGU-4), neuroprotection

Abstract

Background: Anesthesiologists should not only save patient’s life as a process, but also enable the patient to recover his/her social life after surgery, given increased longevity, high social activity throughout life, and increased use of technical equipment in everyday life.

Purpose: To assess central nervous system (CNS) changes in patients undergoing penetrating keratoplasty in order to optimize the choice of anesthesia technique, while taking into account the impact of general anesthesia on postoperative cognitive functions.

Material and Methods: We employed neuropsychological tests such as Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB) and Luria’s test to examine the cognitive function of patients before surgery and 6 hours, 24 hours, 7 days and 21 days after surgery.

Results: On the basis of comparative analysis of the impact of selected anesthesia methods on cognitive function of patients undergoing surgery (penetrating keratoplasty), we concluded that a combination of regional anesthesia (pterygopalatine fossa blockade), dexmedetomidine infusion (0.3 µg/kg) and general analgesia (maintenance in an oxygen/sevoflurane mixture) with exclusion of Sibazon 0.5% had the shortest and the least profound impact on the cognitive function.

Conclusion: On the basis of comparative analysis of the impact of selected anesthesia methods on cognitive function of patients undergoing penetrating keratoplasty, we concluded that a combination of regional anesthesia (pterygopalatine fossa blockade), dexmedetomidine infusion (0.3 µg/kg) and general analgesia (maintenance in an oxygen/sevoflurane mixture) with removal of Sibazon 0.5% from premedication and presence of a reduced amount of fentanyl used during anesthesia had the shortest (with a mean duration of a day) and the least profound impact on cognitive state in patients undergoing ophthalmic surgery.

Author Biographies

G.S. Dorofeeva, Dnipropetrovsk Regional Clinical Eye Hospital

Anesthesiologist

V.P. Aleksieiev, Dnipropetrovsk Regional Clinical Eye Hospital

Anesthesiologist

O.V. Aleksieieva, Dnipro State Medical University

Assistant

I.A. Drapak, Dnipropetrovsk Regional Clinical Eye Hospital

Anesthesiologist

References

Новицкая-Усенко ЛВ. Послеоперационная когнитивная дисфункция в практике врача-анестезиолога. Медицина неотложных сотояний.2017;83(4):9-15.

Усенко ЛВ, Кріштафор АА, Полинчук ИС, Тютюнник АГ, Усенко АА, Петрашенок ЕВ. Послеоперационные когнитивные расстройства как осложнение общей анестезии. Значение ранней фармакологической нейропротекции. Медицина неотложных состояний. 2015;65(2):24-31. https://doi.org/10.22141/2224-0586.2.65.2015.79419

Трінус КФ. Когнітивні розлади та вестибулярні порушення. Міжнародний неврологічний журнал. 2014; 3 (65). https://doi.org/10.22141/2224-0713.3.65.2014.81140

Калашник Л. Лечение когнитивного дефицита при болезни Альцгеймера. Нейро Neys психоневрологія та нейропсихіатрія.2016;10(84):42-46.

Ayvardgi AA, Kobeliatskyy YuYu. ANI-monitoringin assessing the effectiveness of the anesthetic management for plastic surgery of the nose. Emergency medicine. 2018. №1(88): 103-107.

Antonomonov MYu. [Mathematical processing and analysis of biomedical data]. Kyiv; 2017:578.

Published

2023-04-25

How to Cite

1.
Sakovych V, Dorofeeva G, Aleksieiev V, Aleksieieva O, Drapak I. Comparative analysis of the impact of selected anesthesia methods on the cognitive function of patients undergoing ophthalmic surgery. J.ophthalmol. (Ukraine) [Internet]. 2023 Apr. 25 [cited 2024 Apr. 22];(2):21-5. Available from: https://ua.ozhurnal.com/index.php/files/article/view/22

Issue

Section

Clinical Ophthalmology

Most read articles by the same author(s)