Possibility of metabolic correction of the functional condition of mitochondria in the retina in different periods of development of experimental diabetes
DOI:
https://doi.org/10.31288/oftalmolzh201428591Keywords:
experimental diabetes, retina, lipoic acid, quercetin, methionineAbstract
Introduction. Importance of the work consists in studying the influence of quercetin and some metabolic preparations in treatment of experimental diabetes.
Purpose. Possibility of correction of the disturbances of the enzymic processes in mitochondria of the retina in experimental diabetes.
Methods. The investigations were made on Wistar white rats with 190—210 g in mass. Three groups of animals with developing diabetes received lipoic acid, perorally, quercetin and methionine (S-adenosylmethionine). Activity of the enzymatic systems of mitochondria of the retina was determined by means of methods of spectrophotometric analysis.
Results. The degree of disturbances of the oxidation-reduction and transport processes in retinal mitochondria in experimental diabetes was noticeably lowered under the influence of preparations of the lipoic acids, quercetin and methionine.
Conclusions. Application of quercetin exerted distinct influence on the condition of the oxidation-reduction and transmembraneous processes in the retinal mitochondria in experimental diabetes. Metabolic preparations (lipoic acid and S-adenosylmethionine) evidently limit disturbances of activity of the enzymatic system of the retinal mitochondria in streptozotocynic diabetes.
References
1.Gladush TI, Baidan EI. Violations of functional state of mitochondrial structures of the retina in experimental diabetes and their possible correction. Oftalmol Zh. 2009;1-2:92-7. Russian.https://doi.org/10.31288/oftalmolzh2009129297
2.Gogina IF, Andriyuk LV, Ogranovych OE. Diabetic angio-, retino-, neuropathy: pathogenesis, clinic, treatment. Lviv: Liga press; 2000. 186 p.
3.Yevgrafov VYu. Diabetic retinopathy: pathogenesis, diagnosis, treatment: author's thesis for Doctor of Medical Sciences. M.; 1996. 47 p.
4.Kravchuk EA. Role of free radical oxidation in the pathogenesis of eye diseases. Vestn Oftalmol. 2004;5:48-51. Russian.
5.Kryzhanovskaya TV. Pathogenetic aspects of rehabilitation of patients with diabetic retinopathy. Proceedings of II International conference «Modern aspects of vascular and endocrine diseases of the visual organ». K.; 2005. 73- 4.
6.Leus NF. Metabolic mechanisms of development and prospects of medical treatment of diabetic retinopathy. Oftalmol Zh. 2003;5:75- 80. Russian.
7.Maltsev EV, Rodin SS, Chernyayev SN. Diabetic retinopathy, mechanisms of development. Oftalmol Zh. 2003; 2:82-8. Russian.
8.Milenkaya TM, Bessmertnaya EG. Diabetic retinopathy. Vrachebnoie delo. 2000;1:8-11. Russian.
9.Naslyedov A. SPSS computer data analysis in psychology and social sciences. SPb.:Piter; 2005. 416 p.
10.Nedzvetskaia OV. Modern trends in treatment of diabetic retinopathy. Mezhdunar. Med. Zhurnal. 2000;3:56-8. Russian.
11.New methods of biochemical analysis. Izd. Leningradskogo univer. 1991. 395 p.
12.Sidorova MV. Diabetic retinopathy. Pathogenesis, clinic, treatment. K.: SMP «AVERS»; 2006. 156 p.
13.Aiello LP, Cahill MT, Wong J. S. Systemic considerations in the management of diabetic retinopathy. Am. J. Ophthalmol. 2001;32:760-76.https://doi.org/10.1016/S0002-9394(01)01124-2
14.Bayness JW. Role of oxidative stress in development of complications in diabetes / Diabetes. 1991;40:405- 12.https://doi.org/10.2337/diabetes.40.4.405
15.Bergmeyer H. U. Methoden der enzymatischen Analyse. Berlin; 1986. 2254-65.
16.Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-20.https://doi.org/10.1038/414813a
17.Dervan E, Lillis D, Flynn L. Factors that influence the patient uptake of diabetic retinoparthy screening. Irish. J. Med. Sci. 2008;177:303-8.https://doi.org/10.1007/s11845-008-0192-5
18.Fong DS, Aiello LP, Ferris FL, Klein RK. Diabetic retinopathy. Ophthalmo. 2004;27:2540-53.https://doi.org/10.2337/diacare.27.10.2540
19.Lang GE. Pharmacological treatment of diabetic retinopathy. Ophthalmologica. 2007;221(2):112-7.https://doi.org/10.1159/000098256
20.Pan H-Z, Zhang H, Chang D et al. The change of oxidative stress products in diabetes mellitus and diabetic retinopathy. Br. J Ophthalmol. 2008;92:548-51.https://doi.org/10.1136/bjo.2007.130542
21.Reyk DM, Gillies MC, Davies MJ. The retina: oxidative stress and diabetes. Redox Rep. 2003;8(4):187- 92.https://doi.org/10.1179/135100003225002673
22.Speicher MA, Danis RP, Criswell M. Pharmacologic therapy for diabetic retinopathy. Expert Opion Emerg Drugs. 2003;8(1):239-50.https://doi.org/10.1517/14728214.8.1.239
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 О. А. Мороз
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.
