Treatment of traumatic optic neuropathy high doses of corticosteroids
DOI:
https://doi.org/10.31288/oftalmolzh201433033Keywords:
traumatic optic neuropathy, high doses of corticosteroids, Methylprednisolone pulse therapyAbstract
Tactics of treatment of traumatic optic neuropathy (TON) is controversial. The use of high doses of corticosteroids is considered the standard of care at the tone in many countries. However, there are still many questions related to the severe side effects of this therapy and the inability to use it in the most optimal period (first 48 hours), when the patient is usually burdened with concomitant lesions. The aim was to discover of treatment of traumatic optic neuropathy with high doses of corticosteroids.
Material and methods. There were treated three patients with TON. Results. The study of medicinal properties of high-dose corticosteroids showed their positive influence in TON. There were detected increasing of visual function and normalization of eye's fundus in the background of pulse therapy with Methylprednisolone. The effect was unstable. Atrophic changes in the optic nerve continued development on the affected side as well as on the opposite side of proving inadequacy of the proposed scheme.
Conclusion. So, high doses of corticosteroids contribute in improving the treatment of TON.
References
1.Alderson P., Roberts I. Corticosteroids for acute traumatic brain injury (Review). - The Cochrane Library. - 2009, issue 3. - 29 p.https://doi.org/10.1002/14651858.CD000196.pub2
2.Anderson R. L. Optic nerve blindness following blunt forehead trauma. / [Anderson R. L.et al.] // Ophthalmology. - 1982. - Vol. 89. - P. 445- 55.https://doi.org/10.1016/S0161-6420(82)34769-7
3.Chou P. I. Clinical experiences in the management of traumatic optic neuropathy / [Chou P. I., Sadun A. A., Chen Y. C., Su W. Y., Lin S. Z., Lee C. C.] // Neurophthalmology. - 1996. - № 18. - P. 325- 336.https://doi.org/10.3109/01658109609044636
4.Cook M. W. Traumatic optic neuropathy. A meta-analysis. / [Cook M. W., Levin L. A., Joseph M. P., Pinczower E. F.] // Arch. Otolaryngol. Head Neck Surg. - 1996. - № 122. - P. 389-392.https://doi.org/10.1001/archotol.1996.01890160031006
5.CRASH Trial Collaborators. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. - Lancet, 2004. - Vol. 364. - P. 1321-1328.https://doi.org/10.1016/S0140-6736(04)17188-2
6.Guy J. Ben Simon. Traumatic Brain Injury Induced Neuroprotection of Retinal Ganglion Cells to Optic Nerve Crush / Guy J. Ben Simon. // Journal of Neurotrauma. - 2006. - Vol. 23(7). - P. 1072- 1082.https://doi.org/10.1089/neu.2006.23.1072
7.Kitthaweesin K. Yospaiboon. Dexamethasone and methylprednisolone in treatment of indirect traumatic optic neuropathy (abstract). / [Kitthaweesin K, Yospaiboon] // J. Med. Assoc. Thai. - 2001. - № 84. - P. 628- 634.
8.Lessell S. Indirect optic nerve trauma. / [Lessell S.] // Arch. Ophthalmol. - 1989. - Vol. 107. - P. 382- 386.https://doi.org/10.1001/archopht.1989.01070010392031
9.Levin L. A. The treatment of traumatic optic neuropathy. The International Optic Nerve Trauma Study. / Levin L. A., Beck R. W., Joseph M. P.] // Ophthalmol¬ogy. - 1999. - № 106. - Р.168- 1277.https://doi.org/10.1016/S0161-6420(99)00707-1
10.Liu D. Prostaglandin release by spinal cord injury mediates production of hydroxyl radical, malondialdehyde and cell death: A site of neuroprotective action of methylpredniso-lone. / [Liu D., Li L., Augustus L.] // J. Neurochem. - 2001.- № 77. - P.1036- 1047.https://doi.org/10.1046/j.1471-4159.2001.00306.x
11.RajiniganthM. G.Traumatic OpticNeuropathyVisualOutcome Following Combined Therapy Protocol / Rajiniganth M. G., Ashok K. Gupta, Amod Gupta, Jayapalli Rajiv Bapuraj // Arch. Otolaryngol Head Neck Surg. - 2003. - Vol. 129. - P.1203-1206.https://doi.org/10.1001/archotol.129.11.1203
12.Seiff S. R. High dose corticosteroids for treatment of vision loss due to indirect injury to the optic nerve / [Seiff S. R.] // Ophthalmic. Surg. - 1990. - Vol. 21. - P.389-395.https://doi.org/10.3928/1542-8877-19900601-04
13.Spoor T. C. Treatment of traumatic optic neuropathy with corticosteroids // Spoor T. C., Hartel W. C., Len-sink D. B. // Am. J. Ophthalmol. - 1990. - № 110. - P.665-669.https://doi.org/10.1016/S0002-9394(14)77065-5
14.Yip C. C. Low-dose intravenous methylprednisolone or conservative treatment in the management of traumatic optic neuropathy. / Yip C. C., Chng N. W., Au Eong K. G., Heng W. J., Lim T. H., Lim W. K. // Eur. J. Ophthalmol. - 2002.- Vol.12 (4). - P. 309- 314.https://doi.org/10.1177/112067210201200410
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