New possibilities of substitution of the lipid layer of the tear film
DOI:
https://doi.org/10.31288/oftalmolzh201531317Keywords:
dry eye, tear film, ectoine, treatmentAbstract
The effect of eye drops «Eye-t® ectoine» containing 0.5 % solution of ectoine on clinical symptoms of dry eye syndrome was studied.
Material i methods. The study was performed in 21 patients (39 eyes) with dry eye syndrome (DES) of moderate severity. Ectoine — natural bioregulator, stabilizes the lipid layer of the tear film, protects the epithelium of the cornea and conjunctiva of hyperosmolarity, moisten the surface of the eye, preventing dehydration. The preparation containing 0.5 % sodium ectoine instilled 6 times per day for 3 weeks.
Results. The clinical results indicate that the use of eye drops «Eye-t® ectoine» in patients with DES increases the stability of the tear film, which results in a significant increase in the time tear firm break and is accompanied by a decrease in subjective symptoms and Ocular Surface Disease Index (OSDI)
References
Zabegailo AO, Polunin GS, Polunina EG, Kasparova EA. Modern ideas about blepharoconjunctival form of dry eye syndrome. Vestnik Oftalmol. 2007; 123 (2): 45-49. In Russian.
Egorov EA, Basinskii SN. Clinical lectures on ophthalmology. Moscow: GEOTAR; 2007. 288 p.
Brzheskii VV. Modern possibilities of substitution of the mucin layer in precorneal tear film. Review. Oftalmologiia. 2011;8(1): 2-7. In Russian.
Maichuk YuF, Zni EV. The preparation of a new pathogenic action in the dry eye treatment. 2011;11 (2):2-7. In Russian.
Gudrun Bischoff, Riad Khaireddin, Lipidsubstitution bei kontaktlinsenassoziiertem Trocken Auge. Aktuelle Kontaktologie. Sept. 2011: 1-4.
Somov EE. Etiopathogenic basis of dry eye syndrome and principles of its treatment. Saint Petersburg. 1-16 October, 2010. 482-487. In Russian.
Marube J, Nemeth J, Hoh K. The triple classification of dry eye for practical and clinical use. Eur. J. Opthalmol. 2005;15:.660-667. https://doi.org/10.1177/112067210501500602
Nichols K, Foulks G, Bron A. The International Workshop of Meibomian Gland dysfunction. Invest. Opthalmol. and Vis. Sci. 2011;52:1917-1929.https://doi.org/10.1167/iovs.10-6997
Klaus Ditzen, Pult Heiko, Die Meibomdruse: Ein Schlusselfaktor fur das Kontaktlinsentragen beim Trockenen Auge? Aktuelle Kontaktologie. Marz/April 2011. 13-7.
Shine WE, McCulley JR. Meiboimian gland secretion polar lipids associated with chronic blepharitis disease groups. Investig. Ophthalmol. Vis. Sci.1996;37:.3926.
Holly FJ, Lemp Ma. Formation and stability of the tear film, In The Preocular Tear Film and Dry Eye Syndromes. Int Ophthalmol Clin. 1973;13(1):73-96.https://doi.org/10.1097/00004397-197301310-00007
Shine WE, McCulley JR. Polar lipids in human meibomian gland secretions. Curr.Eye Res. 2003;26:89-94.https://doi.org/10.1076/ceyr.26.2.89.14515
Butovich IA, Wojtovicz JC, Molai M. Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum. J. Lipid Res. 2009;50:2471-2485.https://doi.org/10.1194/jlr.M900252-JLR200
Butovich IA, Uchiyama E, McCulley JP. Lipids of human meibum: mass-spectrometric abalysis and stuctural elucidation. J. Lipid Res. 2007;48: 2220-2235.https://doi.org/10.1194/jlr.M700237-JLR200
Butovich IA, Uchiyama E, Di Pascuale MA, McCulley JP. Liquid chromatography- mass spectrometric analysis of lipids present in human meibomian gland secretions. Lipids. 2007. 2:765-776.https://doi.org/10.1007/s11745-007-3080-2
Harischandra RK, Sachan AK, Kerth A et al. Compatible solutes: ectoine and hydroxyestoine improve functional nanostructures in artifitial lung surfactants. Biochim Biophys. Acta. 2011;1808: 2830-2840.https://doi.org/10.1016/j.bbamem.2011.08.022
Wollensak G, Mur A, Mayr A, Baier G, Gottinger W, Stoffler G. Effective methods for the investigation of human tear film proteins and lipids. Graefes Arch. Clin. Exp.1990;.228:.78-82.https://doi.org/10.1007/BF02764296
Galinski EA, Preiffer HP, Truper HG. 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidine-carboxylic acid - a novel cyclic amino-acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira. Eur. J. Biochem. 1985;149:135-139.https://doi.org/10.1111/j.1432-1033.1985.tb08903.x
Lippert K, Galinski EA. Enzyme stabilization at ectoine-type compatible solutes - protection against heating, frezing and during. Appl. Microbiol. Biotechnol. 1992;37:61-65.https://doi.org/10.1007/BF00174204
Harischandra RK, Wulff S, Lentzen G et al. The effects of compatible solute ectoine on the stuctural organization of lipid monolayer and bilayer membranes. Biochimical chemistry. 2010;150(1-3):37-46.https://doi.org/10.1016/j.bpc.2010.02.007
Bradley E Dougberty, Jason J Nichols, Kelly K Nicbols. Rasch Analysis of the Ocular Surface Disease. Invest. Ophthalmol. Vis. Sci. 2011;52(12):8630-8635.https://doi.org/10.1167/iovs.11-8027
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Г. И. Дрожжина, Л. Ф. Тройченко
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.
