Influence of the light effect on the antioxidant system in the retina in experimental uveitis
DOI:
https://doi.org/10.31288/oftalmolzh201328992Keywords:
simulated retinal degeneration, uveal inflammation, antioxidant enzymesAbstract
In the study we investigated the activity of antioxidant enzymes (glutathione per- oxidase, catalase and superoxide dismutase) in the retina of rabbits in modeling age-related macular degeneration in allergic inflammation of the uveal tract. Found that of AMD against uveitis leads to a significant inhibition of antioxidant enzymes, especially superoxide dismutase.
References
1.Астахов Ю. С, Лисочкина А. Б., Шадричев Ф. Е. Возрастная макулярная дегенерация. Клинические рекомендации. Офтальмология // Под ред. Л. К. Мошетовой, А. П. Нестерова, Е. А. Егорова. М.: ГЭО-Медиа, 2006. - С. 164-188.
2.Киселева Т. Н., Полунин Г. С., Елисеева Э. Г., Лагутина Ю. М. Современные аспекты патогенеза и клиники возрастной макулярной дегенерации // Офтальмология. - 2005. - Т.2. - № 1. - С. 18-23.
3.Новые методы биохимического анализа. // Изд. Ле-нинградского универ. - 1991. - 395 с.
4.Реброва О. Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA / О. Ю. Реброва. - М.: Медиа Сфера, 2002. - С. 312. Савко В. В., Вашах Зияд Махмуд Ахмед. Влияние воспалительного процесса в увеальном тракте на развитие патологических изменений в сетчатке кроликов при световом воздействии // Офталь-мол. журн. - 2011. - № 1. - С. 61-64.
5.Савко В. В., Вашах Зияд Махмуд Ахмед. Влияние воспаления в увеальном тракте на процессы перекисного окисления липидов в сетчатке животных при длительном световом воздействии // Офтальмол. журн. - 2012. - № 1. - С. 52-55.
6.Солдатова А. М. Роль свободнорадикальных, окислительно-восстановительных процессов и видимого света в патогенезе склеротической макуло-дистрофии / Офтальмол. журн. - 1992. - № 5-6. - С.273-280.
7.Age-related Eye Disease Study Research Group. A ran-domized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss // Arch. Ophthalmol. - 2001. - Vol. 119. - P. 1417-1436. https://doi.org/10.1001/archopht.119.10.1417
8.Algevre P. V., Marshall J., Seregard S. Age-related macu-lopathy and the impact of blue light hazard // Acta Ophthalmol. Scand. - 2006. - Vol. 84. - № 1. - P. 4-15.https://doi.org/10.1111/j.1600-0420.2005.00627.x
9.Algevre P. V., Seregard S. Age-related maculopathy: pathogenetic features and new treatment modalities // Acta Ophthalmol. - 2002. - Vol. 80. - P. 136-143.https://doi.org/10.1034/j.1600-0420.2002.800204.x
10.Baker M. L., Wang J. J., Rogers S. Early age-related macu-lar degeneration, cognitive function, and dementia / Arch Ophthalmol. - 2009. - Vol. 127. - № 5. - P. 667-673.https://doi.org/10.1001/archophthalmol.2009.30
11.Beatty S., Koh H. H., Henson D. The role of oxidative stress in the pathogenesis of age-related macular degeneration // Surv. Ophthalmol. - 2000. - Vol. 45. - № 2. -P. 115-134.https://doi.org/10.1016/S0039-6257(00)00140-5
12.Delcourt C., Cristol J. P., Tessier F. Age-related macular degeneration and antioxidant status in the POLA study / Arch. Ophthalmol. - 1999. - Vol. 117. - P. 1384¬1390.https://doi.org/10.1001/archopht.117.10.1384
13.Donoso L. A., Kim D., Frost A. The role of inflammation in the pathogenesis of age-related macular degeneration // Surv. Ophthalmol. - 2006. - Vol. 51. - № 2. - P. 137-152.https://doi.org/10.1016/j.survophthal.2005.12.001
14.Klein R., Knudtson M. D., Klein B. E., Wong T. Y. Inflammation, complement factor h, and age-related macular degeneration: the Multi-ethnic Study of Ath¬erosclerosis // Ophthalmology. - 2008. - Vol. 115. - № 10. - P. 1742-1749.https://doi.org/10.1016/j.ophtha.2008.03.021
15.Liang F. Q., Godley B. F. Oxidative stress-induced mi-tochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration // Exp. Eye Res. - 2003. - Vol. 76. - № 4. - P. 397-403.https://doi.org/10.1016/S0014-4835(03)00023-X
16.Mares J. A., Moeller S. M. Diet and age-related macular degeneration: expanding our view // Am. J. Clin. Nutr. - 2006. - Vol. 83. - P. 733-734.https://doi.org/10.1093/ajcn/83.4.733
17.Ozawa Y., Ishida S., Tsubota K. Age-related macular degeneration (AMD); From pathogenesis and approved therapies to proposed treatments for prevention // Anti-Aging Medicine. - 2008. - Vol. 5. - № 9. - P. 87- 92.https://doi.org/10.3793/jaam.5.87
18.Paulus T. V. M. de Jong Age-related macular degeneration // N. Engl. J. Med. - 2006. - Vol. 355. - P. 1474- 1485.https://doi.org/10.1056/NEJMra062326
19.Redmer van Leeuwen, Klaver C. C. W., Vigerling J. R. The risk and natural course of age-related maculopathy // Arch. Ophthalmol. - 2003. - Vol. 121. - P. 519- 526.https://doi.org/10.1001/archopht.121.4.519
20.Silvestry G. Age-related macular degeneration: genetics and implications for detection and treatment // Mol. Med. Today. - 1997. - Vol. 3. - P. 84-91.https://doi.org/10.1016/S1357-4310(96)10057-5
21.Weng T. X., Godley B. F., Jin G. F. Oxidant and antioxidant modulation of chloride channels expressed in human retinal pigment epithelium // Am. J. Physiol. Cell Physi-ol. - 2002. - Vol. 283. - P. C839-C849.https://doi.org/10.1152/ajpcell.00445.2001
22.Winkler B. S., Boulton M. E., Gottsch J. D. Oxidative damage and age-related macular degeneration / Mol. Vis. - 1999. - Vol. 5. - 32- 38.
Downloads
Published
Issue
Section
License
Copyright (c) 2013 В. В. Савко, Вашах Зияд Махмуд Ахмед
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.
