Changes in incidence rates of retinopathy of prematurity in Odessa region in the years of 2009 to 2016
DOI:
https://doi.org/10.31288/oftalmolzh201752125Keywords:
retinopathy of prematurity, demographic situationAbstract
Background. Although retinopathy of prematurity (ROP) is a wide-spread disease, statistical data are absent; so studying the incidence of ROP in Ukraine is of importance.
Purpose. To study the incidence of retinopathy of prematurity in Odessa oblast (region) in children whose birth weights were < 2500 g.
Material and Methods. We followed up 2682 premature babies. The initial examination was performed at four to six weeks after children’s birth. The examination included ophthalmoscopy under medical mydriasis using a binocular forehead ophthalmoscope with aspheric lenses of 20 and 30 D. The examination findings were registered according to recommendations of the International Committee for Retinopathy of Prematurity and following the International Classification of Retinopathy of Prematurity (ICROP). Analysis was processed using softwares MedCalc v.16.8.4 (MedCalc SoftWare bvba, 1993-2016) and MedStat (Lyakh Yu.E., Gurianov V.G. 2004 – 2011).
Results. The mean values for the period of 2009-2016 were 24.7% (95% CI: 18.2- 31.7%) for ROP incidence rates; 19.4% (95% CI: 13.6-25.9%) for stage 1-2 ROP; 4.9% (95% CI: 3.3-6.8%) for ROP cases requiring laser treatment. The stage 1-2 ROP incidence was 47.6% and 87.9% in 2009 and 2016, respectively (p<0.001 according to the Chi-squared test for the presence of the trend for the ordered categories).
Conclusions. The incidence of retinopathy of prematurity increased in Odessa Oblast from 10% in 2009 to 27% in 2016. The incidence of stage 1-2 ROP increased from 4.7 % in 2009 to 23.8 % in 2016. The incidence of stage 3 ROP decreased to 2.3% in 2016 vs. 5.2% in 2009. In 2016, aggressive posterior ROP was diagnosed in 1.0 % of cases. The frequency of laser treatment decreased to 3.3% in 2016 compared to 5.2% in 2009.
References
1. Petrie A, Sabin C. [Medical Statistics at a Glance]. Translated from English, V.P. Leonov, translator. M.: GEOTAR-Media; 2003. 144 p. Russian.
2.Rykov SA, Barinov YV. [Modern ways of solving the problems of blindness and low vision due to retinopathy of prematurity in Ukraine]. Oftalmologiia. Vostochnaia Evropa; 2012;3(14):12-7. Russian.
3.Anil Narang, Amod Gupta, Vinekar et al. Retinopathy of prematurity in Asian Indian babies weighing greater than 1250 grams at birth: ten year data from a tertiary care center in a developing countryю Indian Journal of Ophthalmology. 2008.Jan; 55(5):331-6.https://doi.org/10.4103/0301-4738.33817
4.Backhouse O. Causes of decreased vision and blindness in Madagascar. Community Eye Health. 1996;17:14-6.
5.Chao Chen, Yequn Zhou, Wenjing Shi. The incidence of retinopathy of prematurity: a prospective multicenter study in China. Word ROP Congress III. 2012. OR-02.
6.Committee for the Classification of Retinopathy of Prematurity. An International Classification of Retinopathy of Prematurity. Arch Ophthalmol. 1984;102:1130-134.https://doi.org/10.1001/archopht.1984.01040030908011
7.Dordi Austeng, Karin BM K?llen, Uwe W Ewald et al. Incidence of Retinopathy of Prematurity in Infants Born Before 27 Weeks' Gestation in Sweden. Arch Ophthalmol.2009;127(10):1315-1319.https://doi.org/10.1001/archophthalmol.2009.244
8.Gilbert C, Foster A. Childhood blindness in the context of VISION 2020 - the right to sight. Bull World Health Organ. 2001:79:227-32.
9.Goggin M, O'Keefe M. Childhood blindness in the Republic of Ireland: a national survey. Br J Ophthalmol. 1991:75:425-9.https://doi.org/10.1136/bjo.75.7.425
10.ICROP Committee for Classification of Late Stages ROP. An international classification of retinopathy of prematurity, II: the classification of retinal detachment. Arch Ophthalmol. 1987:105:906-12.https://doi.org/10.1001/archopht.1987.01060070042025
11.International Committee for the Classification of Retinopathy of Prematurity. The international classification of retinopathy of prematurity revisited. Arch Ophthalmol. 2005:123(7):991-9.https://doi.org/10.1001/archopht.123.7.991
12.Juan Carlos Silva. Epidemiology of ROP in Latin America. Word ROP Congress III. 2012. OR-03.
13.Mahmoud Nassar. Screening for Retinopathy of Prematurity: The first report from Upper Egypt. Word ROP Congress III. 2012. OR-07.
14.Phan MH, Nguyen PN, Reynolds JD. Incidence and severity of Retinopathy of Prematurity in Vietnam, a developing middle-income country. J Pediatr Ophthalmol Strabismus. 2003;40:208-12.https://doi.org/10.3928/0191-3913-20030701-07
15.Section on Ophthalmology American Academy of Pediatrics; American Academy of Ophthalmology; American Association for Pediatric Ophthalmology and Strabismus. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2006;117:572-6.https://doi.org/10.1542/peds.2005-2749
16.Steinkuller PG, Du L, Gilbert C, Foster A, Collins ML, Coats DK. Childhood blindness. J AAPOS.1999;3(1): 26-32.https://doi.org/10.1016/S1091-8531(99)70091-1
17.Chen Y, Li X. Characteristics of severe retinopathy of prematurity patients in China: a repeat of the first epidemic? Br J Ophthalmol. 2006;Mar 90(3):268 - 71.https://doi.org/10.1136/bjo.2005.078063
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 С. В. Кацан, Е. С. Заичко
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.
