The study of the clinical signs of the inflammatory process in the cornea in simultaneous modeling of keratitis and conjunctivitis in the experiment
DOI:
https://doi.org/10.31288/oftalmolzh201328388Keywords:
experimental keratitis, conjunctivitisAbstract
Presents the results of experimental research, which indicates, that the presence of inflammation in the conjunctiva greatly increases the clinical signs, that characterize the intensity of inflammation in the cornea modeling keratitis. The degree of inflammation and swelling of the cornea, in the middle of the observation period increased compared with those in animals only when playing experimental keratitis.
References
1.Дрожжина Г. И., Каменская Е. В. Влияние факовита и тауфона на особенности клинического течения поверхностного герпетического кератита // Офтальмол. журн. - 2008. - № 2. - С. 44-48.
2.Дрожжина Г. И., Гайдамака Т. Б., Каменская Е. В. Изменение концентрации тиоловых соединений в роговице при развитии моделированного герпетического кератита // Дистрофічні захворюванню органа зору: XIV Міжнародний наук. симпозіум «Одеса-Генуя», 8-9 вересня 2005 р.: тези. - Одеса, 2005. -С. 33-34.
3.Каменская Е. В. Эффективность медикаментозной коррекции нарушений тиолового статуса при поверхностных формах герпетического кератита: автореф. дис. канд. мед. наук: спец. 14.01.18 «Офтальмология» / Е. В. Каменская. - Одесса, 2008. - 20 с.
4.Майчук Ю. Ф. Современные тенденции в эпидемиологии и терапии глазных инфекций // Окулист. -2005. - № 6 (74). - С. 8-9.
5.Наследов А. SPSS компьютерный анализ данных в психологии и социальных науках / Наследов А. - Спб.: Питер, 2005. - 416 с.
6.Петруня А. М., Мухамед Абдульрахман Кутайни. Изучение обменных процессов в роговице при экспериментальном кератите и конъюнктивите // Проблеми екологічної та медичної генетики і клінічної імунології. - 2012. - Вип. 3 (111). - С. 205-221.
7.Петруня А. М., Мухамед Абдульрахман Кутайни. Исследование тиолового обмена и окислительно-восстановительных процессов в роговице при экспериментальном конъюнктивите // Проблеми екологічної та медичної генетики і клінічної імунології. - 2012. - Вип. 1 (109). - С. 259-272.
8.Abu el-Asrar A. M., Geboes K., Tabbara K. F. Immuno-pathogenesis of vernal keratoconjunctivitis // Bull Soc Belge Ophthalmol. - 1996. - Vol. 261. - P. 15-24.
9.Bourcier T. Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases / Bourcier T., Thomas F, Borderie V. // Br. J. Ophthalmol. - 2003. -Vol. 87. - P. 834- 838.https://doi.org/10.1136/bjo.87.7.834
10.Ciriolo M. R. Loss of GSH, Oxidative stress, and Decrease of Intracellular pH as Sequential Steps in Viral Infection / Ciriolo M. R., Palamara A. T., Incerpi S. // The J. Biolog. Chem. - 1997. - V. 272, № 5. - P. 2700- 2708.https://doi.org/10.1074/jbc.272.5.2700
11.Dickinson D. A. Cellular glutathione and thiols metabolism / Dickinson D. A., Forman H. J. // Biochem. Pharmacol. - 2002. - Vol. 64. - P. 1019- 1026.https://doi.org/10.1016/S0006-2952(02)01172-3
12.Douset O., Lanvin M., Thillou C. Reconstituted human corneal epithelium: a new alternative to the Draize eye test for the assessment of the eye irritation potential of chemicals and cosmetic products // Toxicol. Votro. - 2006. - Vol. 20. - P. 499-512. https://doi.org/10.1016/j.tiv.2005.09.005
13.Friend J., Hassell J. R. Biochemistry of the cornea In: Kaufman H. E., Barron B. A., McDonalds H. B. eds. The Cornea. - New York: Churchill Livingstone. - 1998. - P. 47-67.
14.Hazlett L. D. Role of innate and adaptive immunity in the pathogenesis of keratitis // Ocul. Immunol. Inflammat. -2005. - Vol. 13. - P. 133- 138. https://doi.org/10.1080/09273940490912362
15.Kannan R., Gukasyan H. J., Wenzheng Z. Impairment of conjunctival glutathione secretion and ion transport by oxidative stress in an adenovirus type 5 ocular infection model of pigmented rabbits // Free Rad. Biol. Med. - 2004. -Vol. 37. - P. 229-238.https://doi.org/10.1016/j.freeradbiomed.2004.04.030
16.Liang H. LPS-stimulated inflammation and apoptosis in corneal injury models / Liang H., Brignole-Baudouin F, Labbe A. // Mol. Vis. - 2007. - Vol. 13. - P. 1169- 1180.
17.Liang H. In vivo confocal microscopy and ex vivo flow cytometry: new tools for assessing ocular inflammation applied to rabbit lipopolisaccharide-induced conjunctivitis / Liang H., Baudouin C., Labbe A. //Mol. Vis. - 2006. -Vol. 12. - P.1392- 1402.
18.Reim M. The redox state of the glutathione in the bovine corneal epithelium / Reim M., Beermann H. R., Luthe P. // Graefes Arch. Klin. Ophthal. - 1976. - Vol. 201. - P. 143-148 https://doi.org/10.1007/BF00410065
19.Schultz C. L. Lipopolysaccharide induced acute red eye and corneal ulcers / Schultz C. L., Morck D. W., McKay S. G. // Exp. Eye Res. - 1997. - Vol. 64. - P. 3-9. https://doi.org/10.1006/exer.1996.0190
20.Schultz C. L. Lipopolysaccharide entry in the damaged cornea and specific uptake by polymorphonuclear neutrophils / Schultz C. L., Buret A. G., Olson M. E. // Infect.Immunity. - 2000. - Vol. 68. - № 3. - P. 1731-1734.https://doi.org/10.1128/IAI.68.3.1731-1734.2000
21.Trinkaus-Randall V. Quantification of stromal destruction in the inflamed cornea / Trinkaus-Randall V., Leibowitz H. M., Ryan W. J. // Invest. Ophthalmol. Vis. Sci. -1991. - Vol. 32. - № 3. - P. 603-609.
22.Whikehart D. R. Total and oxidized glutathione in bovine corneal epithelium and endothelium / Whikehart D. R. // Exp. Eye Res. - 1975. - Vol. 21. - P. 89- 92.https://doi.org/10.1016/0014-4835(75)90060-3
23.Wilson S. E., Liu J. J., Mohan R. R. Stromal-epithelial interactions in the cornea // Prog. Retin Eye Res. - 1999. - Vol. 18. - P. 293- 309.https://doi.org/10.1016/S1350-9462(98)00017-2
24.Yuan X., Wilhelmus K. R., Matoba A. Y Pathogenesis and outcome of paecilomyces Keratitis // Am. J. Ophthal¬mol. - 2009. - Vol. 147. - P. 691- 696.https://doi.org/10.1016/j.ajo.2008.11.016
Downloads
Published
Issue
Section
License
Copyright (c) 2013 А. М. Петруня, Мухамед Абдульрахман Кутайни

This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.







