Study of etiologic factors for optic atrophy
DOI:
https://doi.org/10.31288/oftalmolzh201924449Keywords:
optic nerve, atrophy, etiologyAbstract
Background: Optic atrophy (OA) is a disease of multiple etiologies and is a consequence of various pathological changes along the optic pathway. Central nervous system (CNS) disorders, vascular impairments and retinal and optic nerve diseases are important in the etiology of this condition.
Purpose: To investigate various etiologic factors for OA.
Materials and Methods: Patients were retrospectively divided into three groups: Group 1 (primary descending OA; 2,046 patients); Group 2 (primary ascending OA; 430 patients); and Group 3 (secondary OA; 190 patients).
Results: Supratentorial tumors prevailed (78.0-79.4%) among the neurosurgical disease causing optic atrophy. Vascular factor was the most common cause (27.6-28.5%) of ascending OA, followed by inflammatory (25.5-30.1%). We found the presence of essential hypertension, diabetes mellitus type 2, and atherosclerosis to be significant medical risk factors for OA, with odds ratios of 2.46 (95% CI = 1.69 to 3.58), 2.32 (95% CI = 1.22 to 4.41), and 2.11 (95% CI = 1.41 to 3.15), respectively.
References
1.Gustov AV, Sigrianskii KI, Stoliarova GhP. [Practical neuroophthalmology in 2 volumes]. N. Novgorod: N. Novgorodskaya gosudarstvennaya medicinskaya academia; 2000.
2.Morosov VI, Yakovlev AA. [Diseases of the visual pathway: Clinical picture, diagnosis and treatment]. Moscow: Binom; 2010.
3.Nikoforov AS, Guseva MR. [Ophthalmoneurology]. Moscow: GEOTAR-Media; 2014.
4.Vitovska OP, Vasyuta VA, Konah VM. [Optic nerve atrophy: main problems and ways of prevention]. Kiev: Tri K; 2016.
5.Chinta S, Wallang BS, Sachdeva V, et al. Etiology and clinical profile of childhood optic nerve atrophy at a tertiary eye care center in South India. Indian J Ophthalmol. 2014; 62(10): 1003-7. https://doi.org/10.4103/0301-4738.145996
6.Mbekeani JN, Fattah MA, Poulsen DM, et al. Etiology of optic atrophy: a prospective observational study from Saudi Arabia. Ann Saudi Med. 2017 May-Jun;37(3): 232-9. https://doi.org/10.5144/0256-4947.2017.232
7.Roodhooft JM. Nonglaucomatous optic disk atrophy and excavation in the elderly. Bull Soc Belge Ophtalmol. 2003;(287): 45-9.
8.Tagoe NN, Essuman VA, Fordjuor G, et al. Neuro-Ophthalmic and Clinical Characteristics of Brain Tumours in a Tertiary Hospital in Ghana. Ghana Med J. 2015 Sep;49(3):181-6.https://doi.org/10.4314/gmj.v49i3.9
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 В. А. Васюта, Ю. Є. Педаченко
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) that allows users to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.
COPYRIGHT NOTICE
Authors who publish in this journal agree to the following terms:
- Authors hold copyright immediately after publication of their works and retain publishing rights without any restrictions.
- The copyright commencement date complies the publication date of the issue, where the article is included in.
DEPOSIT POLICY
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) during the editorial process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work with an acknowledgement of its initial publication in this journal.
- Post-print (post-refereeing manuscript version) and publisher's PDF-version self-archiving is allowed.
- Archiving the pre-print (pre-refereeing manuscript version) not allowed.
