THE ANALYSIS OF THE INFLUENCE OF DIODE LASER TRABECULOPLASTY AB EXTERNO ON THE LEVEL OF THE TRANSFORMING GROWTH FACTOR IN THE AQUEOUS HUMOR OF THE ANTERIOR CHAMBER IN PATIENTS WITH OPEN ANGLE GLAUCOMA
DOI:
https://doi.org/10.31288/oftalmolzh201311416Keywords:
відкритокутова глаукома, глибока непроникаюча склеректомія, лазерна трабекуло-пластика, внутрішньоочний тиск, трансформуючий фактор росту бета 2, позаклітинний матриксAbstract
Thirty four patients (34 eyes) with uncontrolled open-angle glaucoma were under treatment. The patients were divided into two groups. Seventeen patients (17 eyes) — the main group — underwent deep sclerectomy combined with diod laser trabeculoplasty ab externo. After aspiration of the aqueous humor of the anterior chamber the level of the transforming growth factor p 2 (TGF p2) was analyzed. The mean TGF p2 level was significantly (p<0,05) higher in the patients in the main group in comparison to the patients of the control group and consisted of 66.72±26.41 pg/ml and 53.79±23.13 pg/ml respectively. The mean level of the intraocular pressure (IOP) in the main group was 28,11±2,31 mm Hg before the surgery and in a year of follow up the number decreasedto 16,51±1,32 Mm.Hg. In the control the figures were as follows: 27,19±1,73 mm Hg and 17,80±1,50 mmHg accordingly. Micropulse laser trabeculoplasty leads to increasing of the TGF p2 level what can inhibit local immune system and cause more effective and smooth healing of the trabecular meshwork after the surgery.
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