Investigation of the optical properties of the lens (according to the instrument «Manual Straylight Meters») and visual acuity in patients with primary senile cataract receiving the drug bioflavonoid — quercetin
DOI:
https://doi.org/10.31288/oftalmolzh201442328Keywords:
primary senile cataract, lens, light scattering, quercetin, lipoflavonAbstract
Introduction. Urgency of the work is determined by elucidating the actions of bioflavonoid — quercetin in the treatment of primary senile cataract. Purpose. To examine the optical properties of the lens and visual acuity in patients with primary senile cataract in the initial form receiving the drug bioflavonoid (quercetin) Methods. Patients participating in this study were divided into two groups. The main group was composed of 45 patients with primary senile cataract treated with Lipoflavon instillation and oral quercetin, and a comparison group of 43 patients with primary senile cataract who did not receive Lipoflavon and quercetin. Eye scattered light was measured in patients with age-related cataract. Results. The results indicate that the drug helps slow the development of quercetin and severity of lens opacities in patients with primary senile cataract. This effect is observed after treatment and occurs throughout the follow-up period of 24 months. Visual acuity at 12, 18 and 24 months of the follow-up in the study group was significantly higher in relation to the comparison group by 6.4, 10.7 and 15.5 %, respectively. Conclusions. The application of quercetin in patients with primary senile cataract leads to a distinct stabilization of existing lens opacities, reducing the intensity of light scattering.
References
1. Веселовская 3. Ф., Боброва Н. Ф., Вит В. В. Катаракта. - Киев: Книга плюс, 2002. - 208 с.
2. Воскресенская Л. К. Патогенез и лечение старческой и диабетической катаракты: автореф. дисс. ... докт. мед. наук: 14.00.16, 14.00.08 «Российский Университет дружбы народов» / Л. К. Воскресенская. - М., 1993. - 32 с.
3. Горшкова Р. А. Клинико-экспериментальные предпосылки применения Липофлавона у больных возрастной катарактой для снижения степени послеоперационной воспалительной реакции // Материалы XXVI Международной научно-практической конференции «Применение лазеров в медицине и биологии». - Ялта, 2006. - С. 115-116. 4. Леус Н. Ф., Гиржева А. В., Журавок Ю. А. Влияние биофлавоноидов (кверцетина и рутина) на развитие патологических изменений в хрусталике при моделировании возрастной катаракты // Офтальмол. журн. - 2010. - № 6. - С. 60- 65.
4. Леус Н. Ф., Будайа Низар, Гиржева А. В. Механизм антикатарактогенного действия каротиноидов и фла-воноидов // Офтальмология. Вост. Европа - 2013. - № 3. - С. 86- 94.
5. Леус Н. Ф., Гиржева А. В., Журавок Ю. А. Влияние кверцетина на ферменты антиоксидантной защиты хрусталика и камерной влаги у больных возрастной катарактой // Материалы XIII Съезда офтальмологов Украины, 21-23 мая. - Одесса, - 2014. - С. 6667.
6. Муранов К. О., Островский М. А. Молекулярная физиология и патология хрусталика глаза. - М.: ТОРУС ПРЕСС, 2013. - 304 с.
7. Наследов А. SPSS компьютерный анализ данных в психологии и социальных науках. // Спб.: Питер, 2005. - 416 с.
8. Пасечникова Н. В., Горшкова Р. А., Гайдамака Т. Б. Предварительная оценка противовоспалительного действия препарата «Липофлавон» у пациентов после экстракапсулярной экстракции катаракты // Офтальмол. журн. - 2005. - № 3. - С. 13-18.
10. Age-related Eye Disease Study Research Group. A Randomized, placebocontrolled, clinical trial of high-dose supplementation with vitamins С and E and beta carotene for age-related cataract and vision loss: AREDS report no // Arch. Ophthalmol. - 2001. - V.119. - № 10. - P. 1439-1452. https://doi.org/10.1001/archopht.119.10.1439
11. Berendschot T. T., Broekmans W. M. R. Lens aging in relations to nutritional determinants and possible risk factors for age-related cataract // Arch. Ophthalmol. - 2002. - Vol.120. - P. 1732- 1737. https://doi.org/10.1001/archopht.120.12.1732
12. Bunce G., Kinoshita J. Nutritional factors in cataract // Ann. Rev. Nutr. - 1990. - Vol. 10. - P. 233- 254. https://doi.org/10.1146/annurev.nu.10.070190.001313
13. Christen W. G. Antioxidant vitamins and age-related eye desease // Proc. Assos. Am. Phisicians. - 1999. - V.111. - № 1. - P.16-21. https://doi.org/10.1046/j.1525-1381.1999.09231.x
14. Congdon N. Preventions strategies for age related cataract: present - limitations and future possibilities // Br. J. Ophthalmol. - 2001. - Vol. 85 (5). - P. 516- 520. https://doi.org/10.1136/bjo.85.5.516
15. De Waard P. W. T. Intraocular light scattering In age-related cataracts // Invest. Ophthalmol. Vis. Sci. - 1992. - Vol. 33. - P. 618-625.
16. Fernandez M. M., Afshari N. A. Nutrition and the prevention of cataracts // Curr. Opin. Ophthalmol. - 2008. - Vol. 19. - № 1. - P. 66- 70. https://doi.org/10.1097/ICU.0b013e3282f2d7b6
17. Hockwin O., Kojima М., Muller-Breitenkamp U. Lens and cataract, research of the 20th century: a review of results, errors and misunderstandings // Dev. Ophthalmol. - 2002. - № 35. - P.1-11. https://doi.org/10.1159/000060803
18. Van den Berg T. J. Intraocular straylight. Studied using the direct compensation technique // CIE 22-nd session, Melbourne. - 1991. - Vol. 1. - P. 83- 84. https://doi.org/10.1364/NAVS.1991.WE1
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