EXPERT CONSENSUS. Treatment approaches to patients with neovascular age-related macular degeneration who need frequent intravitreal injections of aflibercept

DOI:

https://doi.org/10.31288/oftalmolzh202218083

Abstract

Treatment approaches to patients with neovascular age-related macular degeneration who need frequent intravitreal injections of aflibercept

References

1.Schmidt-Erfurth U, Chong V, Loewenstein A, et al. Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA). Br J Ophthalmol. 2014; 98:1144-1167. https://doi.org/10.1136/bjophthalmol-2014-305702

2.Lanzetta P, Loewenstein A; Vision Academy Steering Committee. Fundamental principles of an anti-VEGF treatment regimen: optimal application of intravitreal anti-vascular endothelial growth factor therapy of macular diseases. Graefes Arch Clin Exp Ophthalmol. 2017; 255:1259-1273. https://doi.org/10.1007/s00417-017-3647-4

3.Giannakaki-Zimmermann H, Ebneter A, Munk MR, et al. Outcomes when switching from a pro re nata regimen to a treat and extend regimen using aflibercept in neovascular age-related macular degeneration. Ophthalmologica 2016; 236:201-206. https://doi.org/10.1159/000452929

4.Mitchell P, Holz FG, Hykin P et al. Efficacy and safety of intravitreal aflibercept using a treat-and-extend regimen for neovascular age-related macular degeneration. Retina 2021; 41:1911-1920. https://doi.org/10.1097/IAE.0000000000003128

5.Wolf S, Holz FG, Hykin P et al. Neovascular age-related macular degeneration (nAMD) treated with intravitreal aflibercept (IVT-AFL) treat-and-extend (T&E): post-hoc analysis of injection intensive (I-I) requirement for patients in the ARIES study. Invest. Ophthalmol. Vis. Sci. 2021; 62(8):423.

6.Guymer RH, Markey CM, McAllister IL et al. Tolerating subretinal fluid in neovascular age-related macular degeneration treated with ranibizumab using a treat-and-extend regimen. Ophthalmology 2019; 126:723-734. https://doi.org/10.1016/j.ophtha.2018.11.025

7.Novartis reports one year results of Phase III MERLIN study evaluating Beovu® every four week dosing and provides update on Beovu clinical program. Available at: https://www.novartis.com/news/media-releases/novartis-reports-one-year-r.

8.Letter of appeal from Novartis to healthcare providers July 5, 2021. Available at: https://www.dec.gov.ua/wp-content/uploads/farmakonaglyad/letter-of-cauti.

Published

2025-08-27

How to Cite

1.
EXPERT CONSENSUS. Treatment approaches to patients with neovascular age-related macular degeneration who need frequent intravitreal injections of aflibercept. J.ophthalmol. (Ukraine) [Internet]. 2025 Aug. 27 [cited 2025 Aug. 28];(1):80-3. Available from: https://ua.ozhurnal.com/index.php/files/article/view/396

Issue

Section

History of Ophthalmology